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- W2631282218 abstract "This chapter starts by metabolism of pyrethroid insecticides in laboratory, focused mainly on in vivo metabolism. There are some species differences in in vitro microsome oxidation sites of allethrin between rats and mice: rat microsomes appear to preferentially oxidize the trans -methyl group of the isobutenyl moiety. On the other hand, the major oxidation sites by mouse microsomes are the trans -methyl group of the isobutenyl group. Male and female rats were treated with 14C bifenthrin labeled in the acid or alcohol moiety at single oral doses of 4 and 35 mg/kg. 14C was rapidly excreted into feces and urine, and the excretion rates of the 14C to feces and urine were 66–83% and 13–25%, respectively. Highest residues were found in the fat with values of slightly more than 1 ppm after low-dose administration and 8 and 16 ppm in males and females, respectively. All the pyrethroid insecticides investigated so far are rapidly metabolized in mammals and their metabolites are almost completely excreted in the urine and feces within several days of a single oral or subcutaneous administration except their cyano moiety. Tissue residues are generally very low, showing that they are biodegradable and nonbioaccumulative." @default.
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- W2631282218 date "2001-01-01" @default.
- W2631282218 modified "2023-09-23" @default.
- W2631282218 title "Pyrethroid Chemistry and Metabolism" @default.
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- W2631282218 doi "https://doi.org/10.1016/b978-012426260-7.50061-6" @default.
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