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- W2631445849 abstract "This chapter provides various examples of two classes of computer models of cortical spreading depression (CSD), all without trying to parse mathematical details; these can be found in the cited original literature. The common theme that runs through these examples is to elucidate how the respective objective of the model determines the chosen level of abstraction. First, it introduces microscopic models that include cellular and cytoarchitectonic detail. A key question addressed by microscopic models concerns which properties of the neuronal membrane contribute to the ignition of CSD. In this case, the computational science process begins by identifying the discussed physiological observations to be selected for a working model. Next, the chapter also introduces macroscopic models that describe large scale pattern formation in cortical tissue and addresses questions raised by the neurological manifestation of CSD. It further deals with some predictions from this computational science approach." @default.
- W2631445849 created "2017-06-30" @default.
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- W2631445849 date "2017-06-19" @default.
- W2631445849 modified "2023-09-23" @default.
- W2631445849 title "Mathematical Modeling of Human Cortical Spreading Depression" @default.
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- W2631445849 doi "https://doi.org/10.1002/9781118967225.ch17" @default.
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