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• W2631720160 abstract "Cardiac myxoma (CM) is a prevalent primary cardiac tumor. miR-217 plays a vital role in tumorigenesis of various cancers, however, its role and underlying molecular mechanism in human CM remain poorly understood. Here, we reported that the expression of miR-217 was downregulated in CM tissues and inversely correlated with the expression of Interleukin-6 (IL-6) mRNA. Gain-of-function analysis indicated that overexpression of miR-217 inhibited the proliferation and promoted the apoptosis of the primary CM cells. Bioinformatics analysis showed that IL-6 was a direct target gene of miR-217, which is confirmed by the dual luciferase assays. Moreover, downregulation of IL-6 by small interference RNA (siRNA) mimicked the tumor-suppressive effects of miR-217 in CM. Furthermore, rescue experiments pointed out that restoration of IL-6 expression abrogated the anti-proliferative and pro-apoptotic effect induced by miR-217 overexpression in CM cells. Taken together, we validated that miR-217 could act as a tumor suppressor in CM by directly targeting 3′UTR of IL-6 gene, indicating that manipulation of miR-217 may be a potential therapeutic strategy for CM patients." @default.
• W2631720160 created "2017-06-30" @default.
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• W2631720160 creator A5052619334 @default.
• W2631720160 creator A5062617254 @default.
• W2631720160 date "2017-08-01" @default.
• W2631720160 modified "2023-09-27" @default.
• W2631720160 title "miR-217 suppresses proliferation and promotes apoptosis in cardiac myxoma by targeting Interleukin-6" @default.
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• W2631720160 doi "https://doi.org/10.1016/j.bbrc.2017.06.106" @default.
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