Matches in SemOpenAlex for { <https://semopenalex.org/work/W2632099862> ?p ?o ?g. }
- W2632099862 endingPage "59" @default.
- W2632099862 startingPage "59" @default.
- W2632099862 abstract "This study explores the delivery of novel calcium hydroxide [Ca(OH)2] microparticles loaded with chlorhexidine (CHX) for potential dental therapeutic and preventive applications. Herein, we introduce a new approach for drug-delivery to deep dentin-surfaces in the form of drug-loaded microparticles. Unloaded Ca(OH)2 [Ca(OH)2/Blank] and CHX-loaded/Ca(OH)2 microparticles were fabricated by aqueous chemical-precipitation technique. The synthesized-microparticles were characterized in vitro for determination of surface-morphology, crystalline-features and thermal-properties examined by energy-dispersive X-ray scanning and transmission electron-microscopy (EDX-SEM/TEM), Fourier-transform infrared-spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and differential scanning-calorimetry (DSC). Time-related pH changes, initial antibacterial/biofilm-abilities and cytotoxicity of CHX-loaded/Ca(OH)2 microparticles were evaluated. Microparticles were delivered to dentin-surfaces with subsequent SEM examination of treated dentin-substrates. The in vitro and ex vivo CHX-release profiles were characterized. Ca(OH)2/Blank were hexagonal-shaped with highest z-average diameter whereas CHX-inclusion evidenced micro-metric spheres with distinguishable surface “rounded deposits” and a negative-shift in diameter. CHX:Ca(OH)2/50 mg exhibited maximum encapsulation-efficiency with good antibacterial and cytocompatible properties. SEM examination revealed an intact layer of microparticles on exposed dentin-surfaces with retention of spherical shape and smooth texture. Microparticles loaded on dentin-surfaces showed prolonged release of CHX indicating substantial retention on dentin-substrates. This study validated the inherent-applicability of this novel drug-delivery approach to dentin-surfaces using micro-metric CHX-loaded/Ca(OH)2 microparticles." @default.
- W2632099862 created "2017-06-30" @default.
- W2632099862 creator A5007410116 @default.
- W2632099862 creator A5031934635 @default.
- W2632099862 creator A5042240125 @default.
- W2632099862 creator A5058719368 @default.
- W2632099862 date "2017-06-22" @default.
- W2632099862 modified "2023-10-14" @default.
- W2632099862 title "Characterization of Chlorhexidine-Loaded Calcium-Hydroxide Microparticles as a Potential Dental Pulp-Capping Material" @default.
- W2632099862 cites W1493527302 @default.
- W2632099862 cites W1522531231 @default.
- W2632099862 cites W1533623243 @default.
- W2632099862 cites W1553349472 @default.
- W2632099862 cites W168152179 @default.
- W2632099862 cites W182557449 @default.
- W2632099862 cites W187529583 @default.
- W2632099862 cites W1935252090 @default.
- W2632099862 cites W1969314495 @default.
- W2632099862 cites W1976846383 @default.
- W2632099862 cites W1980425172 @default.
- W2632099862 cites W1983207530 @default.
- W2632099862 cites W1985462926 @default.
- W2632099862 cites W1998042566 @default.
- W2632099862 cites W2004456199 @default.
- W2632099862 cites W2012256489 @default.
- W2632099862 cites W2017221878 @default.
- W2632099862 cites W2018081847 @default.
- W2632099862 cites W2018419373 @default.
- W2632099862 cites W2019347117 @default.
- W2632099862 cites W2020109428 @default.
- W2632099862 cites W2020359713 @default.
- W2632099862 cites W2043842656 @default.
- W2632099862 cites W2055085006 @default.
- W2632099862 cites W2059658187 @default.
- W2632099862 cites W2060223317 @default.
- W2632099862 cites W2061209546 @default.
- W2632099862 cites W2061684485 @default.
- W2632099862 cites W2061954426 @default.
- W2632099862 cites W2062239202 @default.
- W2632099862 cites W2062533190 @default.
- W2632099862 cites W2068014362 @default.
- W2632099862 cites W2074433735 @default.
- W2632099862 cites W2075074322 @default.
- W2632099862 cites W2080936059 @default.
- W2632099862 cites W2082164260 @default.
- W2632099862 cites W2084551722 @default.
- W2632099862 cites W2090266672 @default.
- W2632099862 cites W209126410 @default.
- W2632099862 cites W2093662752 @default.
- W2632099862 cites W2096235587 @default.
- W2632099862 cites W2102597480 @default.
- W2632099862 cites W2115091240 @default.
- W2632099862 cites W2119932234 @default.
- W2632099862 cites W2126682272 @default.
- W2632099862 cites W2133218448 @default.
- W2632099862 cites W2140033444 @default.
- W2632099862 cites W2152051146 @default.
- W2632099862 cites W2153400936 @default.
- W2632099862 cites W2158317221 @default.
- W2632099862 cites W2160996126 @default.
- W2632099862 cites W2162313608 @default.
- W2632099862 cites W2163332599 @default.
- W2632099862 cites W2176278825 @default.
- W2632099862 cites W2216709393 @default.
- W2632099862 cites W2327168125 @default.
- W2632099862 cites W2342776409 @default.
- W2632099862 cites W2408593291 @default.
- W2632099862 cites W2412120984 @default.
- W2632099862 cites W2463014704 @default.
- W2632099862 cites W256162486 @default.
- W2632099862 cites W30282006 @default.
- W2632099862 cites W4296537731 @default.
- W2632099862 cites W4319308272 @default.
- W2632099862 cites W88187797 @default.
- W2632099862 cites W1786200695 @default.
- W2632099862 doi "https://doi.org/10.3390/bioengineering4030059" @default.
- W2632099862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5615305" @default.
- W2632099862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28952538" @default.
- W2632099862 hasPublicationYear "2017" @default.
- W2632099862 type Work @default.
- W2632099862 sameAs 2632099862 @default.
- W2632099862 citedByCount "17" @default.
- W2632099862 countsByYear W26320998622018 @default.
- W2632099862 countsByYear W26320998622019 @default.
- W2632099862 countsByYear W26320998622020 @default.
- W2632099862 countsByYear W26320998622021 @default.
- W2632099862 countsByYear W26320998622023 @default.
- W2632099862 crossrefType "journal-article" @default.
- W2632099862 hasAuthorship W2632099862A5007410116 @default.
- W2632099862 hasAuthorship W2632099862A5031934635 @default.
- W2632099862 hasAuthorship W2632099862A5042240125 @default.
- W2632099862 hasAuthorship W2632099862A5058719368 @default.
- W2632099862 hasBestOaLocation W26320998621 @default.
- W2632099862 hasConcept C121332964 @default.
- W2632099862 hasConcept C127413603 @default.
- W2632099862 hasConcept C13965031 @default.
- W2632099862 hasConcept C159985019 @default.
- W2632099862 hasConcept C160892712 @default.