FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2632640766> ?p ?o ?g. }

• W2632640766 endingPage "1881" @default.
• W2632640766 startingPage "1873" @default.
• W2632640766 abstract "There are substantial global differences in the preference for mercaptopurine (MP) or its prodrug azathioprine (AZA) as first-choice thiopurine to treat inflammatory bowel diseases. Studies comparing both agents are scarce. Our aim was to compare AZA and MP in thiopurine-naive patients with inflammatory bowel disease for the frequency of side effects and efficacy.Post hoc analysis of the Thiopurine response Optimization by Pharmacogenetic testing in Inflammatory bowel disease Clinics (TOPIC) trial, in which thiopurine-naive patients with inflammatory bowel disease with an indication for a thiopurine were randomized for a genotype-based dose versus standard of care. For this study, Cox proportional hazard ratios (HRs) were calculated to compare AZA and MP for discontinuation rates within 5 months, incidence of hepatotoxicity, leukopenia, and gastrointestinal side effects. Treatment efficacy was compared by logistic regression.Patient characteristics were similar for patients treated with AZA (n = 494, 64.4%) and MP (n = 273, 35.6%), yet patients with MP were relatively higher dosed compared with those on AZA. Discontinuation rates within 5 months were not different, 39.3% (AZA) and 38.1% (MP), HR 0.92 (95% confidence interval, 0.72-1.17; P = 0.50); however, patients on MP were more often subjected to dose reductions (30% versus 14%, P < 0.01). Higher rates of hepatotoxicity, HR 1.93 (95% confidence interval, 1.35-2.76; P < 0.01) and leukopenia, HR 2.55 (95% confidence interval, 1.51-4.30; P < 0.01) were observed with MP, which annulled in a secondary analysis with adjustment for the higher dose and metabolite levels.Patients treated with MP were relatively higher dosed, which resulted in more dose-dependent side effects and a higher rate of dose reductions." @default.
• W2632640766 created "2017-06-30" @default.
• W2632640766 creator A5008894367 @default.
• W2632640766 creator A5014977080 @default.
• W2632640766 creator A5030957904 @default.
• W2632640766 creator A5034703202 @default.
• W2632640766 creator A5038962814 @default.
• W2632640766 creator A5041755268 @default.
• W2632640766 creator A5047169308 @default.
• W2632640766 creator A5051633802 @default.
• W2632640766 creator A5065293355 @default.
• W2632640766 creator A5071390124 @default.
• W2632640766 creator A5078377172 @default.
• W2632640766 creator A5087444104 @default.
• W2632640766 date "2017-10-01" @default.
• W2632640766 modified "2023-10-01" @default.
• W2632640766 title "More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing" @default.
• W2632640766 cites W1063009109 @default.
• W2632640766 cites W1499566049 @default.
• W2632640766 cites W1856238840 @default.
• W2632640766 cites W1921213064 @default.
• W2632640766 cites W1970611979 @default.
• W2632640766 cites W1972388266 @default.
• W2632640766 cites W1984690893 @default.
• W2632640766 cites W1985761386 @default.
• W2632640766 cites W2004115250 @default.
• W2632640766 cites W2025343624 @default.
• W2632640766 cites W2030973366 @default.
• W2632640766 cites W2035746880 @default.
• W2632640766 cites W2051544696 @default.
• W2632640766 cites W2054045668 @default.
• W2632640766 cites W2056547521 @default.
• W2632640766 cites W2056586250 @default.
• W2632640766 cites W2073895882 @default.
• W2632640766 cites W2075352120 @default.
• W2632640766 cites W2077346034 @default.
• W2632640766 cites W2077677554 @default.
• W2632640766 cites W2079528157 @default.
• W2632640766 cites W2104539207 @default.
• W2632640766 cites W2107194846 @default.
• W2632640766 cites W2108236283 @default.
• W2632640766 cites W2110286478 @default.
• W2632640766 cites W2126807394 @default.
• W2632640766 cites W2129897459 @default.
• W2632640766 cites W2145648574 @default.
• W2632640766 cites W2145649264 @default.
• W2632640766 cites W2149633671 @default.
• W2632640766 cites W2151447037 @default.
• W2632640766 cites W2156250460 @default.
• W2632640766 cites W2160237124 @default.
• W2632640766 cites W2188717288 @default.
• W2632640766 cites W2349662145 @default.
• W2632640766 cites W2463541557 @default.
• W2632640766 cites W2523706394 @default.
• W2632640766 cites W2531543608 @default.
• W2632640766 cites W2545245219 @default.
• W2632640766 cites W2551234537 @default.
• W2632640766 cites W2561670050 @default.
• W2632640766 cites W2565820977 @default.
• W2632640766 cites W38847137 @default.
• W2632640766 cites W4231630787 @default.
• W2632640766 doi "https://doi.org/10.1097/mib.0000000000001163" @default.
• W2632640766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5598908" @default.
• W2632640766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28644183" @default.
• W2632640766 hasPublicationYear "2017" @default.
• W2632640766 type Work @default.
• W2632640766 sameAs 2632640766 @default.
• W2632640766 citedByCount "23" @default.
• W2632640766 countsByYear W26326407662017 @default.
• W2632640766 countsByYear W26326407662018 @default.
• W2632640766 countsByYear W26326407662019 @default.
• W2632640766 countsByYear W26326407662020 @default.
• W2632640766 countsByYear W26326407662021 @default.
• W2632640766 countsByYear W26326407662022 @default.
• W2632640766 countsByYear W26326407662023 @default.
• W2632640766 crossrefType "journal-article" @default.
• W2632640766 hasAuthorship W2632640766A5008894367 @default.
• W2632640766 hasAuthorship W2632640766A5014977080 @default.
• W2632640766 hasAuthorship W2632640766A5030957904 @default.
• W2632640766 hasAuthorship W2632640766A5034703202 @default.
• W2632640766 hasAuthorship W2632640766A5038962814 @default.
• W2632640766 hasAuthorship W2632640766A5041755268 @default.
• W2632640766 hasAuthorship W2632640766A5047169308 @default.
• W2632640766 hasAuthorship W2632640766A5051633802 @default.
• W2632640766 hasAuthorship W2632640766A5065293355 @default.
• W2632640766 hasAuthorship W2632640766A5071390124 @default.
• W2632640766 hasAuthorship W2632640766A5078377172 @default.
• W2632640766 hasAuthorship W2632640766A5087444104 @default.
• W2632640766 hasBestOaLocation W26326407661 @default.
• W2632640766 hasConcept C126322002 @default.
• W2632640766 hasConcept C207103383 @default.
• W2632640766 hasConcept C2776760755 @default.
• W2632640766 hasConcept C2777173762 @default.
• W2632640766 hasConcept C2777288759 @default.
• W2632640766 hasConcept C2778260677 @default.
• W2632640766 hasConcept C2778715236 @default.
• W2632640766 hasConcept C2779134260 @default.
• W2632640766 hasConcept C2780479503 @default.

• next