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- W26329282 abstract "13 Objectives To measure Ki (%/min) from Patlak-Rutland graphical analysis in normal brain from grey matter (GM) and white matter (WM) to enable uptake in tumour regions to be objectively assessed. Methods Dynamic PET [18F]-FET scans (1 frame/min) were acquired for 20 mins from injection in subjects (N=13) with known primary brain tumours and suspected recurrence. Ki for all voxels was derived by graphical analysis from linear regression with an image-derived blood input function generating a parametric image. Co-registered contemporaneous MRI scans were segmented into probabalistic GM and WM regions using SPM8 (Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London). The cerebral hemisphere containing the known tumour was excised from the masks and the remaining brain tissue used to derive mean Ki values for all voxels with >50% probability of being GM or WM. The Ki values were compared with those in regions of known tumour. Results Mean Ki was 0.181±0.041 %/min for GM and 0.189±0.036 %/min for WM with 95% CIs of 0.156-0.207 %/min and 0.168-0.211 %/min respectively. The paired differences between GM and WM Ki within individuals were not significant (mean difference = -0.008 %/min). The correlation coefficient of Ki between GM and WM was r=0.94 with p Conclusions No difference was measured in uptake rate of FET in GM and WM in normal brain during the first 20 minutes after injection. Therefore, comparison of tumour Ki with normal brain does not need to differentiate between GM and WM thus simplifying the analysis. FET uptake in regions of disease can be assessed as the relative increase in relation to areas of mixed grey/white matter from assumed normal brain." @default.
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- W26329282 date "2013-05-01" @default.
- W26329282 modified "2023-09-23" @default.
- W26329282 title "Normal values for uptake rate constant (Ki) for [18F]-fluoroethyl-L-tyrosine (FET) in brain" @default.
- W26329282 hasPublicationYear "2013" @default.
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