Matches in SemOpenAlex for { <https://semopenalex.org/work/W2633013695> ?p ?o ?g. }
- W2633013695 endingPage "204" @default.
- W2633013695 startingPage "195" @default.
- W2633013695 abstract "Adult C57BL/6J mice have been used to study Foot-and-mouth disease virus (FMDV) biology. In this work, two variants of an FMDV A/Arg/01 strain exhibiting differential pathogenicity in adult mice were identified and characterized: a non-lethal virus (A01NL) caused mild signs of disease, whereas a lethal virus (A01L) caused death within 24-48h independently of the dose used. Both viruses caused a systemic infection with pathological changes in the exocrine pancreas. Virus A01L reached higher viral loads in plasma and organs of inoculated mice as well as increased replication in an ovine kidney cell line. Complete consensus sequences revealed 6 non-synonymous changes between A01L and A10NL genomes that might be linked to replication differences, as suggested by in silico prediction studies. Our results highlight the biological significance of discrete genomic variations and reinforce the usefulness of this animal model to study viral determinants of lethality." @default.
- W2633013695 created "2017-06-30" @default.
- W2633013695 creator A5039841192 @default.
- W2633013695 creator A5045836759 @default.
- W2633013695 creator A5048612175 @default.
- W2633013695 creator A5051517954 @default.
- W2633013695 creator A5061917861 @default.
- W2633013695 creator A5074343525 @default.
- W2633013695 creator A5079679486 @default.
- W2633013695 creator A5081505042 @default.
- W2633013695 creator A5085072058 @default.
- W2633013695 date "2017-09-01" @default.
- W2633013695 modified "2023-10-14" @default.
- W2633013695 title "Differential replication of Foot-and-mouth disease viruses in mice determine lethality" @default.
- W2633013695 cites W1411119344 @default.
- W2633013695 cites W1757744415 @default.
- W2633013695 cites W1873992124 @default.
- W2633013695 cites W1964367064 @default.
- W2633013695 cites W1976054811 @default.
- W2633013695 cites W1978908436 @default.
- W2633013695 cites W1983134928 @default.
- W2633013695 cites W1986361144 @default.
- W2633013695 cites W1988724578 @default.
- W2633013695 cites W1992963933 @default.
- W2633013695 cites W1997432409 @default.
- W2633013695 cites W2002713410 @default.
- W2633013695 cites W2015452923 @default.
- W2633013695 cites W2023880697 @default.
- W2633013695 cites W2023899898 @default.
- W2633013695 cites W2035711496 @default.
- W2633013695 cites W2037321341 @default.
- W2633013695 cites W2040118548 @default.
- W2633013695 cites W2040722089 @default.
- W2633013695 cites W2041877620 @default.
- W2633013695 cites W2042754675 @default.
- W2633013695 cites W2043101137 @default.
- W2633013695 cites W2044101918 @default.
- W2633013695 cites W2044574821 @default.
- W2633013695 cites W2052765715 @default.
- W2633013695 cites W2056494905 @default.
- W2633013695 cites W2058201868 @default.
- W2633013695 cites W2058659491 @default.
- W2633013695 cites W2060900703 @default.
- W2633013695 cites W2061381685 @default.
- W2633013695 cites W2063120318 @default.
- W2633013695 cites W2064520243 @default.
- W2633013695 cites W2066940382 @default.
- W2633013695 cites W2069663555 @default.
- W2633013695 cites W2074517161 @default.
- W2633013695 cites W2085547777 @default.
- W2633013695 cites W2094591288 @default.
- W2633013695 cites W2096147013 @default.
- W2633013695 cites W2097556093 @default.
- W2633013695 cites W2099540110 @default.
- W2633013695 cites W2100984490 @default.
- W2633013695 cites W2103738533 @default.
- W2633013695 cites W2103906844 @default.
- W2633013695 cites W2109185045 @default.
- W2633013695 cites W2111463222 @default.
- W2633013695 cites W2117873191 @default.
- W2633013695 cites W2123540768 @default.
- W2633013695 cites W2132629607 @default.
- W2633013695 cites W2135716413 @default.
- W2633013695 cites W2141157874 @default.
- W2633013695 cites W2150444353 @default.
- W2633013695 cites W2152301430 @default.
- W2633013695 cites W2158266834 @default.
- W2633013695 cites W2158714788 @default.
- W2633013695 cites W2158773127 @default.
- W2633013695 cites W2160236872 @default.
- W2633013695 cites W2165015301 @default.
- W2633013695 cites W2287027531 @default.
- W2633013695 doi "https://doi.org/10.1016/j.virol.2017.06.012" @default.
- W2633013695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28647507" @default.
- W2633013695 hasPublicationYear "2017" @default.
- W2633013695 type Work @default.
- W2633013695 sameAs 2633013695 @default.
- W2633013695 citedByCount "3" @default.
- W2633013695 countsByYear W26330136952019 @default.
- W2633013695 countsByYear W26330136952022 @default.
- W2633013695 crossrefType "journal-article" @default.
- W2633013695 hasAuthorship W2633013695A5039841192 @default.
- W2633013695 hasAuthorship W2633013695A5045836759 @default.
- W2633013695 hasAuthorship W2633013695A5048612175 @default.
- W2633013695 hasAuthorship W2633013695A5051517954 @default.
- W2633013695 hasAuthorship W2633013695A5061917861 @default.
- W2633013695 hasAuthorship W2633013695A5074343525 @default.
- W2633013695 hasAuthorship W2633013695A5079679486 @default.
- W2633013695 hasAuthorship W2633013695A5081505042 @default.
- W2633013695 hasAuthorship W2633013695A5085072058 @default.
- W2633013695 hasBestOaLocation W26330136951 @default.
- W2633013695 hasConcept C104317684 @default.
- W2633013695 hasConcept C140704245 @default.
- W2633013695 hasConcept C141231307 @default.
- W2633013695 hasConcept C142724271 @default.
- W2633013695 hasConcept C159047783 @default.
- W2633013695 hasConcept C20379349 @default.
- W2633013695 hasConcept C2522874641 @default.