Matches in SemOpenAlex for { <https://semopenalex.org/work/W2633164039> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2633164039 abstract "Mesenchymal stromal cells (MSCs) represent one of the most important component of tissue microenvironment. They can be characterized by high proliferative and regenerative potential as well as low immunogenicity that serves MSC application for regenerative therapy. The same properties make them the key players in the pathogenesis of different diseases. Most of these physiological and pathological processes involving MSCs are accompanied by reactive oxygen species (ROS). However, the ROS effects on MSC functional activity are still poorly investigated. In present study we demonstrated that ROS can modify MSC immunogenicity. MSCs were obtained from stromal vascular fraction of human adipose tissue. Intracellular ROS were induced by low fluence (0.25 J/cm2) photodynamic treatment (PDT) with Al-phthalocynine. We demonstrated that low-fluence PDT significantly increase MSC immunogenicity as manifested by decreased MSC viability after co-culture with human peripheral blood mononuclear cells PBMNs. It was accompanied by enhanced FasL expression in MSCs. In addition, it was found out that intracellular ROS induction resulted in dramatic decrease of CCL2 and increase of IL8 but not IL6 production by MSCs. Low-fluence PDT did not affect Fas, MICA/B, Nectin-2, HLA-ABC expression in MSC as well as co-cultivation with PDT-MSC did not influence the expression of DNAM-1, NKG2D and CD69 in NK." @default.
- W2633164039 created "2017-06-30" @default.
- W2633164039 creator A5003695045 @default.
- W2633164039 creator A5046742340 @default.
- W2633164039 creator A5047151903 @default.
- W2633164039 creator A5060706823 @default.
- W2633164039 date "2017-07-01" @default.
- W2633164039 modified "2023-09-27" @default.
- W2633164039 title "Low-fluence photodynamic treatment modifies immunogenicity of mesenchymal stromal cells" @default.
- W2633164039 doi "https://doi.org/10.1016/j.freeradbiomed.2017.04.270" @default.
- W2633164039 hasPublicationYear "2017" @default.
- W2633164039 type Work @default.
- W2633164039 sameAs 2633164039 @default.
- W2633164039 citedByCount "0" @default.
- W2633164039 crossrefType "journal-article" @default.
- W2633164039 hasAuthorship W2633164039A5003695045 @default.
- W2633164039 hasAuthorship W2633164039A5046742340 @default.
- W2633164039 hasAuthorship W2633164039A5047151903 @default.
- W2633164039 hasAuthorship W2633164039A5060706823 @default.
- W2633164039 hasConcept C109316439 @default.
- W2633164039 hasConcept C137061746 @default.
- W2633164039 hasConcept C16930146 @default.
- W2633164039 hasConcept C178790620 @default.
- W2633164039 hasConcept C185592680 @default.
- W2633164039 hasConcept C198826908 @default.
- W2633164039 hasConcept C202751555 @default.
- W2633164039 hasConcept C203014093 @default.
- W2633164039 hasConcept C2778867473 @default.
- W2633164039 hasConcept C2780868878 @default.
- W2633164039 hasConcept C2781323092 @default.
- W2633164039 hasConcept C502942594 @default.
- W2633164039 hasConcept C55493867 @default.
- W2633164039 hasConcept C86803240 @default.
- W2633164039 hasConcept C8891405 @default.
- W2633164039 hasConcept C95444343 @default.
- W2633164039 hasConceptScore W2633164039C109316439 @default.
- W2633164039 hasConceptScore W2633164039C137061746 @default.
- W2633164039 hasConceptScore W2633164039C16930146 @default.
- W2633164039 hasConceptScore W2633164039C178790620 @default.
- W2633164039 hasConceptScore W2633164039C185592680 @default.
- W2633164039 hasConceptScore W2633164039C198826908 @default.
- W2633164039 hasConceptScore W2633164039C202751555 @default.
- W2633164039 hasConceptScore W2633164039C203014093 @default.
- W2633164039 hasConceptScore W2633164039C2778867473 @default.
- W2633164039 hasConceptScore W2633164039C2780868878 @default.
- W2633164039 hasConceptScore W2633164039C2781323092 @default.
- W2633164039 hasConceptScore W2633164039C502942594 @default.
- W2633164039 hasConceptScore W2633164039C55493867 @default.
- W2633164039 hasConceptScore W2633164039C86803240 @default.
- W2633164039 hasConceptScore W2633164039C8891405 @default.
- W2633164039 hasConceptScore W2633164039C95444343 @default.
- W2633164039 hasLocation W26331640391 @default.
- W2633164039 hasOpenAccess W2633164039 @default.
- W2633164039 hasPrimaryLocation W26331640391 @default.
- W2633164039 hasRelatedWork W137480488 @default.
- W2633164039 hasRelatedWork W1548414090 @default.
- W2633164039 hasRelatedWork W1830142691 @default.
- W2633164039 hasRelatedWork W2078653911 @default.
- W2633164039 hasRelatedWork W2152437489 @default.
- W2633164039 hasRelatedWork W2312353032 @default.
- W2633164039 hasRelatedWork W2315168003 @default.
- W2633164039 hasRelatedWork W2396272094 @default.
- W2633164039 hasRelatedWork W2398854767 @default.
- W2633164039 hasRelatedWork W2496771059 @default.
- W2633164039 hasRelatedWork W2521190706 @default.
- W2633164039 hasRelatedWork W2601542415 @default.
- W2633164039 hasRelatedWork W2751632681 @default.
- W2633164039 hasRelatedWork W2768278929 @default.
- W2633164039 hasRelatedWork W2900925307 @default.
- W2633164039 hasRelatedWork W2917173868 @default.
- W2633164039 hasRelatedWork W2945524045 @default.
- W2633164039 hasRelatedWork W3121713112 @default.
- W2633164039 hasRelatedWork W3131564564 @default.
- W2633164039 hasRelatedWork W3139472514 @default.
- W2633164039 isParatext "false" @default.
- W2633164039 isRetracted "false" @default.
- W2633164039 magId "2633164039" @default.
- W2633164039 workType "article" @default.