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- W26342791 abstract "Transmissible diseases are re-emerging as a global problem, with Sexually Transmitted Diseases (STDs) becoming endemic. Chlamydia trachomatis is the leading cause of bacterially-acquired STD worldwide, with the Australian cost of infection estimated at $90 - $160 million annually. Studies using animal models of genital tract Chlamydia infection suggested that the hormonal status of the genital tract epithelium at the time of exposure may influence the outcome of infection. Oral contraceptive use also increased the risk of contracting chlamydial infections compared to women not using contraception. Generally it was suggested that the outcome of chlamydial infection is determined in part by the hormonal status of the epithelium at the time of exposure. Using the human endolmetrial cell line ECC-1 this study investigated the effects of C. trachomatis serovar D infection, in conjunction with the female sex hormones, 17β-estradiol and progesterone, on chlamydial gene expression. While previous studies have examined the host response, this is the first study to examine C.trachomatis gene expression under different hormonal conditions. We have highlighted a basic model of C. trachomatis gene regulation in the presence of steroid hormones by identifying 60 genes that were regulated by addition of estradiol and/or progesterone. In addition, the third chapter of this thesis discussed and compared the significance of the current findings in the context of data from other research groups to improve our understanding of the molecular basis of chlamydial persistence under hormonal different conditions. In addition, this study analysed the effects of these female sex hormones and C. trachomatis Serovar D infection, on host susceptibility and bacterial growth. Our results clearly demonstrated that addition of steroid hormones not only had a great impact on the level of infectivity of epithelial cells with C.trachomatis serovar D, but also the morphology of chlamydial inclusions was affected by hormone supplementation." @default.
- W26342791 created "2016-06-24" @default.
- W26342791 creator A5033318638 @default.
- W26342791 date "2009-01-01" @default.
- W26342791 modified "2023-09-24" @default.
- W26342791 title "Effect of female sex hormones on Chlamydia trachomatis growth and gene expression" @default.
- W26342791 cites W121877279 @default.
- W26342791 cites W1481770753 @default.
- W26342791 cites W1526573723 @default.
- W26342791 cites W1527043063 @default.
- W26342791 cites W1574086949 @default.
- W26342791 cites W1607829858 @default.
- W26342791 cites W1649271653 @default.
- W26342791 cites W173476976 @default.
- W26342791 cites W1845841410 @default.
- W26342791 cites W1848970261 @default.
- W26342791 cites W1863749431 @default.
- W26342791 cites W1878895457 @default.
- W26342791 cites W1882330487 @default.
- W26342791 cites W1886776405 @default.
- W26342791 cites W1890701869 @default.
- W26342791 cites W1895861514 @default.
- W26342791 cites W1911376021 @default.
- W26342791 cites W1939457844 @default.
- W26342791 cites W1943043103 @default.
- W26342791 cites W1945589050 @default.
- W26342791 cites W1955598123 @default.
- W26342791 cites W1956455923 @default.
- W26342791 cites W1963704916 @default.
- W26342791 cites W1965431730 @default.
- W26342791 cites W1965811117 @default.
- W26342791 cites W1967020365 @default.
- W26342791 cites W1970160926 @default.
- W26342791 cites W1971652191 @default.
- W26342791 cites W1972384032 @default.
- W26342791 cites W1972591652 @default.
- W26342791 cites W1972630690 @default.
- W26342791 cites W1975925983 @default.
- W26342791 cites W1977480382 @default.
- W26342791 cites W1977611647 @default.
- W26342791 cites W1977890732 @default.
- W26342791 cites W1979667319 @default.
- W26342791 cites W1984587054 @default.
- W26342791 cites W1986669114 @default.
- W26342791 cites W1987491686 @default.
- W26342791 cites W1988028901 @default.
- W26342791 cites W1993529021 @default.
- W26342791 cites W1993768789 @default.
- W26342791 cites W1997043437 @default.
- W26342791 cites W1999796150 @default.
- W26342791 cites W2001213681 @default.
- W26342791 cites W2001328358 @default.
- W26342791 cites W2002705610 @default.
- W26342791 cites W2005069502 @default.
- W26342791 cites W2009650130 @default.
- W26342791 cites W2017704051 @default.
- W26342791 cites W2022071938 @default.
- W26342791 cites W2022589147 @default.
- W26342791 cites W2025837117 @default.
- W26342791 cites W2028110266 @default.
- W26342791 cites W2029743976 @default.
- W26342791 cites W2031048539 @default.
- W26342791 cites W2035351408 @default.
- W26342791 cites W2035610898 @default.
- W26342791 cites W2036371924 @default.
- W26342791 cites W2037378706 @default.
- W26342791 cites W2038294351 @default.
- W26342791 cites W2039568609 @default.
- W26342791 cites W2039663215 @default.
- W26342791 cites W2039787369 @default.
- W26342791 cites W2040832608 @default.
- W26342791 cites W2042055876 @default.
- W26342791 cites W2044767152 @default.
- W26342791 cites W2047686105 @default.
- W26342791 cites W2050606772 @default.
- W26342791 cites W2052884528 @default.
- W26342791 cites W2053081966 @default.
- W26342791 cites W2054073666 @default.
- W26342791 cites W2057815563 @default.
- W26342791 cites W2059477431 @default.
- W26342791 cites W2060507084 @default.
- W26342791 cites W2061139863 @default.
- W26342791 cites W2061203889 @default.
- W26342791 cites W2061673718 @default.
- W26342791 cites W2063698734 @default.
- W26342791 cites W2067992642 @default.
- W26342791 cites W2069164737 @default.
- W26342791 cites W2070332227 @default.
- W26342791 cites W2074214702 @default.
- W26342791 cites W2076320472 @default.
- W26342791 cites W2078989932 @default.
- W26342791 cites W2079586703 @default.
- W26342791 cites W2079881856 @default.
- W26342791 cites W2080938566 @default.
- W26342791 cites W2085591709 @default.
- W26342791 cites W2085726755 @default.
- W26342791 cites W2090946351 @default.
- W26342791 cites W2094039218 @default.
- W26342791 cites W2095634386 @default.
- W26342791 cites W2095775470 @default.