Matches in SemOpenAlex for { <https://semopenalex.org/work/W2634502983> ?p ?o ?g. }
- W2634502983 endingPage "242" @default.
- W2634502983 startingPage "235" @default.
- W2634502983 abstract "The skin offers an attractive way for dermal and transdermal drug delivery that is why the drug still needs certain qualities to transcend the outermost layer of the skin, the stratum corneum. The requirements are: drugs with a maximum molecular weight of 1 kDa, high lipophilicity and a certain polarity. This would restrict the use of a transdermal delivery of macromolecules, which would make the drug more effective in therapeutic administration. Various studies have shown that macromolecules without support do not penetrate the human skin. This effect can be achieved using physical and chemical methods, as well as biological peptides. The most popular physical method is the use of microneedles to create micropores in the skin and release the active agent in different sections. But also, other methods have been tested. Microjets, lasers, electroporation, sonophoresis and iontophoresis are also promising methods to successfully deliver dermal and transdermal macromolecules. Additionally, there are different penetration enhancer groups and biological peptides, which are also considered to be interesting approaches of enabling macromolecules to travel along the skin. All these methods will be described and evaluated in this review article." @default.
- W2634502983 created "2017-06-30" @default.
- W2634502983 creator A5017046198 @default.
- W2634502983 creator A5024349208 @default.
- W2634502983 creator A5067047003 @default.
- W2634502983 date "2017-10-01" @default.
- W2634502983 modified "2023-10-04" @default.
- W2634502983 title "Dermal and transdermal delivery of pharmaceutically relevant macromolecules" @default.
- W2634502983 cites W1550353272 @default.
- W2634502983 cites W1556915790 @default.
- W2634502983 cites W1596484490 @default.
- W2634502983 cites W1965758660 @default.
- W2634502983 cites W1968770683 @default.
- W2634502983 cites W1969447336 @default.
- W2634502983 cites W1971452794 @default.
- W2634502983 cites W1974536247 @default.
- W2634502983 cites W1981411479 @default.
- W2634502983 cites W1981760171 @default.
- W2634502983 cites W1982169917 @default.
- W2634502983 cites W1984334763 @default.
- W2634502983 cites W1987027319 @default.
- W2634502983 cites W1988066317 @default.
- W2634502983 cites W1988624193 @default.
- W2634502983 cites W1994653828 @default.
- W2634502983 cites W2001293346 @default.
- W2634502983 cites W2001421714 @default.
- W2634502983 cites W2002218627 @default.
- W2634502983 cites W2005255215 @default.
- W2634502983 cites W2013315584 @default.
- W2634502983 cites W2016181184 @default.
- W2634502983 cites W2029017454 @default.
- W2634502983 cites W2029970405 @default.
- W2634502983 cites W2036465226 @default.
- W2634502983 cites W2039628058 @default.
- W2634502983 cites W2065588526 @default.
- W2634502983 cites W2066749703 @default.
- W2634502983 cites W2072752444 @default.
- W2634502983 cites W2076458733 @default.
- W2634502983 cites W2080430067 @default.
- W2634502983 cites W2080888762 @default.
- W2634502983 cites W2082938781 @default.
- W2634502983 cites W2091124269 @default.
- W2634502983 cites W2092125001 @default.
- W2634502983 cites W2100062287 @default.
- W2634502983 cites W2101899631 @default.
- W2634502983 cites W2109261849 @default.
- W2634502983 cites W2109670216 @default.
- W2634502983 cites W2120175055 @default.
- W2634502983 cites W2121060467 @default.
- W2634502983 cites W2140854438 @default.
- W2634502983 cites W2143616792 @default.
- W2634502983 cites W2145499557 @default.
- W2634502983 cites W2172513978 @default.
- W2634502983 cites W2180164052 @default.
- W2634502983 cites W2323591873 @default.
- W2634502983 cites W2323946904 @default.
- W2634502983 cites W2324937562 @default.
- W2634502983 cites W2328918441 @default.
- W2634502983 cites W2395119647 @default.
- W2634502983 cites W2404278137 @default.
- W2634502983 cites W2470780332 @default.
- W2634502983 cites W2511782286 @default.
- W2634502983 cites W2513825140 @default.
- W2634502983 cites W2557144774 @default.
- W2634502983 cites W2564076115 @default.
- W2634502983 cites W2566575831 @default.
- W2634502983 cites W2571239998 @default.
- W2634502983 cites W2604310803 @default.
- W2634502983 cites W4240821889 @default.
- W2634502983 doi "https://doi.org/10.1016/j.ejpb.2017.06.019" @default.
- W2634502983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28647443" @default.
- W2634502983 hasPublicationYear "2017" @default.
- W2634502983 type Work @default.
- W2634502983 sameAs 2634502983 @default.
- W2634502983 citedByCount "94" @default.
- W2634502983 countsByYear W26345029832018 @default.
- W2634502983 countsByYear W26345029832019 @default.
- W2634502983 countsByYear W26345029832020 @default.
- W2634502983 countsByYear W26345029832021 @default.
- W2634502983 countsByYear W26345029832022 @default.
- W2634502983 countsByYear W26345029832023 @default.
- W2634502983 crossrefType "journal-article" @default.
- W2634502983 hasAuthorship W2634502983A5017046198 @default.
- W2634502983 hasAuthorship W2634502983A5024349208 @default.
- W2634502983 hasAuthorship W2634502983A5067047003 @default.
- W2634502983 hasConcept C104317684 @default.
- W2634502983 hasConcept C126838900 @default.
- W2634502983 hasConcept C127413603 @default.
- W2634502983 hasConcept C136229726 @default.
- W2634502983 hasConcept C142724271 @default.
- W2634502983 hasConcept C171250308 @default.
- W2634502983 hasConcept C178790620 @default.
- W2634502983 hasConcept C183529106 @default.
- W2634502983 hasConcept C185592680 @default.
- W2634502983 hasConcept C186852380 @default.
- W2634502983 hasConcept C192562407 @default.
- W2634502983 hasConcept C201399114 @default.
- W2634502983 hasConcept C204389451 @default.