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- W2636750004 abstract "Dasatinib is a small‐molecule tyrosine kinase inhibitor used in the treatment of hematological malignancies. Pulmonary arterial hypertension (PAH) is a rare but known complication. The mainstay of treatment is cessation of Dasatinib, and while clinical improvement is rapid, complete hemodynamic resolution of pulmonary hypertension (PH) still remains exceedingly uncommon. We present a case of Dasatinib‐induced PAH in a woman with chronic myeloid leukemia, who demonstrated rapid and complete clinical and hemodynamic resolution following treatment with combination pulmonary vasodilator therapy using an endothelin receptor antagonist and a phosphodiesterase‐5 inhibitor. This case suggests there may be an association between the use of targeted PH medication in combination and the complete resolution of dasatinib‐associated PAH, but further investigation is required." @default.
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- W2636750004 date "2017-07-01" @default.
- W2636750004 modified "2023-10-16" @default.
- W2636750004 title "Combination targeted pulmonary hypertension therapy in the resolution of Dasatinib‐associated pulmonary arterial hypertension" @default.
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- W2636750004 doi "https://doi.org/10.1177/2045893217716659" @default.
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