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• W2638850746 abstract "ABSTRACT A single protein can bind and regulate many mRNAs. Multiple proteins with similar specificities often bind and control overlapping sets of mRNAs. Yet, little is known about the architecture or dynamics of overlapped networks. We focused on three proteins with similar structures and related RNA-binding specificities – Puf3p, Puf4p, and Puf5p of S. cerevisiae . Using RNA Tagging, we identified a “super-network” comprised of four sub-networks: Puf3p, Puf4p, and Puf5p sub-networks, and one controlled by both Puf4p and Puf5p. The architecture of individual subnetworks, and thus the super-network, are determined by competition among particular PUF proteins to bind mRNAs, their affinities for binding elements, and the abundances of the proteins. The super-network responds dramatically: the remaining network can either expand or contract. These strikingly opposite outcomes are determined by an interplay between the relative abundance of the RNAs and proteins, and their affinities for one another. The diverse interplay between overlapping RNA-protein networks provides versatile opportunities for regulation and evolution." @default.
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• W2638850746 date "2017-06-20" @default.
• W2638850746 modified "2023-10-03" @default.
• W2638850746 title "Architecture and dynamics of overlapped RNA regulatory networks" @default.
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• W2638850746 doi "https://doi.org/10.1101/152991" @default.
• W2638850746 hasPublicationYear "2017" @default.
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