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- W2640495786 abstract "Chronic hepatitis B (CHB) is traditionally thought to progress through distinct disease phases; HBeAg positive chronic infection, HBeAg positive chronic hepatitis, HBeAg negative chronic infection and HBeAg negative chronic hepatitis (formerly referred to as immune tolerant, immune clearance, immune control and immune escape respectively). 1 European Association for the Study of the LiverEASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2017; 67: 370-398 Abstract Full Text Full Text PDF PubMed Scopus (2953) Google Scholar , 2 Zoulim F. Mason W.S. Reasons to consider earlier treatment of chronic HBV infections. Gut. 2012; 61: 333-336 Crossref PubMed Scopus (84) Google Scholar Treatment is usually reserved for those patients with HBeAg positive or negative chronic hepatitis, with evidence of clinically active disease and the presence of fibrosis. [1] European Association for the Study of the LiverEASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2017; 67: 370-398 Abstract Full Text Full Text PDF PubMed Scopus (2953) Google Scholar Treatment candidacy has been largely based on biochemical and virological parameters, however, recent data have demonstrated that the early phase of the disease may not be as benign as previously believed; thus these patients may benefit from early treatment. 2 Zoulim F. Mason W.S. Reasons to consider earlier treatment of chronic HBV infections. Gut. 2012; 61: 333-336 Crossref PubMed Scopus (84) Google Scholar , 3 Kennedy P.T. et al. Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B. Gastroenterology. 2012; 143: 637-645 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar , 4 Mason W.S. et al. HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant. Gastroenterology. 2016; 151: 986-998e984 Abstract Full Text Full Text PDF PubMed Scopus (248) Google Scholar In addition, it is widely recognised that antiviral therapy can prevent cirrhosis and reduce the development of hepatocellular carcinoma (HCC). [5] Marcellin P. et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet. 2013; 381: 468-475 Abstract Full Text Full Text PDF PubMed Scopus (1233) Google Scholar In this article we discuss currently licensed therapies, along with novel pipeline therapies for HBV and their impact on host-viral immunity." @default.
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- W2640495786 date "2017-08-01" @default.
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- W2640495786 title "Current therapeutic approaches for HBV infected patients" @default.
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- W2640495786 doi "https://doi.org/10.1016/j.jhep.2017.04.015" @default.
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