Matches in SemOpenAlex for { <https://semopenalex.org/work/W2642043957> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- W2642043957 abstract "A developing embryo, consisting initially of identical cells, transforms itself into a spatially organized structure made of distinct tissues with clear boundaries. This process, known as pattern formation, is studied in the eld of developmental biology. Cell interaction plays a key role in pattern formation, and the community e ect is an example of such an interaction. A population of cells in an embryo is said to exhibit a community e ect when they form a cell community with a common identity by virtue of exchanging di usible signalling molecules (morphogens). This e ect helps the cell community to maintain a common gene expression pro le over an extended period of time, and to eventually di erentiate co-ordinately into a functional tissue, such as muscle. Self-organizing processes like community e ects are di cult to understand intuitively. Instead, a satisfactory description can be given in the form of a formal model. Several computational models of community e ects were given in the literature. However, the concept of space was not explicitly included in these models, making it di cult to understand how community e ects participate in pattern formation. In this work, we study the behaviour of a community e ect in space and investigate its roles in other pattern formation processes, using computational modelling. Main contributions of this thesis are the following: * A model reduction method is developed for stochastic analysis, and using it we have shown how the model of the community e ect in Xenopus is in uenced by stochastic noise. * Using the simplest possible spatial community e ect model, we show that the community e ect must eventually spread across the entire population of cells which respond to the morphogen. This is con rmed in a more detailed model. * Two models demonstrating how this expansion can be controlled are presented. First, if the community e ect is augmented with a negative feedback mechanism, it forms a reaction-di usion system which self-organizes and forms a stable, localized area of activation. Second, when a simple cross-repression gene circuitry is combined with a community e ect loop, a gene expression pattern with a well-demarcated boundary appears in response to a transient morphogen gradient. The pattern remains stable even after the gradient disappears, which shows that the gene network has the memory of morphogen dynamics." @default.
- W2642043957 created "2017-06-30" @default.
- W2642043957 creator A5082889438 @default.
- W2642043957 date "2014-03-26" @default.
- W2642043957 modified "2023-09-25" @default.
- W2642043957 title "Spatial modelling of community effects" @default.
- W2642043957 hasPublicationYear "2014" @default.
- W2642043957 type Work @default.
- W2642043957 sameAs 2642043957 @default.
- W2642043957 citedByCount "0" @default.
- W2642043957 crossrefType "dissertation" @default.
- W2642043957 hasAuthorship W2642043957A5082889438 @default.
- W2642043957 hasConcept C104317684 @default.
- W2642043957 hasConcept C144024400 @default.
- W2642043957 hasConcept C149923435 @default.
- W2642043957 hasConcept C15744967 @default.
- W2642043957 hasConcept C188147891 @default.
- W2642043957 hasConcept C2779535977 @default.
- W2642043957 hasConcept C2908647359 @default.
- W2642043957 hasConcept C41008148 @default.
- W2642043957 hasConcept C54355233 @default.
- W2642043957 hasConcept C86803240 @default.
- W2642043957 hasConceptScore W2642043957C104317684 @default.
- W2642043957 hasConceptScore W2642043957C144024400 @default.
- W2642043957 hasConceptScore W2642043957C149923435 @default.
- W2642043957 hasConceptScore W2642043957C15744967 @default.
- W2642043957 hasConceptScore W2642043957C188147891 @default.
- W2642043957 hasConceptScore W2642043957C2779535977 @default.
- W2642043957 hasConceptScore W2642043957C2908647359 @default.
- W2642043957 hasConceptScore W2642043957C41008148 @default.
- W2642043957 hasConceptScore W2642043957C54355233 @default.
- W2642043957 hasConceptScore W2642043957C86803240 @default.
- W2642043957 hasLocation W26420439571 @default.
- W2642043957 hasOpenAccess W2642043957 @default.
- W2642043957 hasPrimaryLocation W26420439571 @default.
- W2642043957 hasRelatedWork W1538908131 @default.
- W2642043957 hasRelatedWork W1966618476 @default.
- W2642043957 hasRelatedWork W2037592763 @default.
- W2642043957 hasRelatedWork W2076817084 @default.
- W2642043957 hasRelatedWork W2122458046 @default.
- W2642043957 hasRelatedWork W2134763495 @default.
- W2642043957 hasRelatedWork W2409802966 @default.
- W2642043957 hasRelatedWork W2913894512 @default.
- W2642043957 isParatext "false" @default.
- W2642043957 isRetracted "false" @default.
- W2642043957 magId "2642043957" @default.
- W2642043957 workType "dissertation" @default.