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- W264297396 abstract "Keratinocytes are the main constituent cells in the epidermis. They form the cornified layers through a sophisticated differentiation process, providing a protective barrier to retain body fluids and to prevent environmental insults. As this process takes place along a pathway that leads to cell cycle arrest and terminal differentiation, specific gene sets should show precise spatiotemporally regulated expression. Keratinocyte differentiation is regulated by numerous factors, including large numbers of signal transduction events and transcription factors. In addition, epigenetic regulatory mechanisms have been emerging as important contributors to spatiotemporal regulation of differentiation-related genes. These include DNA methylation, histone modification, and microRNA interference. Although sufficient information has not yet been accumulated to fully understand the epigenetic modulation of gene expression, it will surely be an important area of research to provide additional data on the regulatory mechanism underlying keratinocyte differentiation. In this chapter, we describe current knowledge on the regulatory mechanisms of gene expression during keratinocyte differentiation, with an emphasis on the role of epigenetic modulation." @default.
- W264297396 created "2016-06-24" @default.
- W264297396 creator A5029957285 @default.
- W264297396 date "2015-01-01" @default.
- W264297396 modified "2023-10-16" @default.
- W264297396 title "Keratinocyte Differentiation and Epigenetics" @default.
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- W264297396 doi "https://doi.org/10.1016/b978-0-12-800957-4.00003-5" @default.
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