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- W264326265 abstract "Bis-dinitro-propyl-formal:bis-dinitro-propyl-acetal (BDNPF:BDNPA) and kerimide 601 resin do not appear to be mutagenic at the doses utilized when introduced intragastrically either as an acute or chronic insult in vivo. It should be pointed out that the dominant lethal assay has limitations. It has been observed by others that positive data with Ames testing can give negative data with this method. To produce a strong mutagenic effect detectable by the dominant lethal assay, there must be considerable chromosome damage in the sperm. The dominant lethal assay does not detect point mutations or low incidence of chromosome breakage. The assay can be valuable in expressing the in vivo effect, which can be contrary to in vitro studies, and should be considered in a total toxicity survey of a chemical. Using the dominant lethal assay, one can screen out a positive mutagen, but lack of an effect does not indicate that the chemical is not mutagenic. It is either not mutagenic or the assay is not specific enough to detect the in vivo effect." @default.
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- W264326265 date "1978-03-01" @default.
- W264326265 modified "2023-09-28" @default.
- W264326265 title "Dominant lethal assay for bis-dinitro-propyl-formal: bis-dinitro-propyl-acetal and kerimide 601 resin" @default.
- W264326265 doi "https://doi.org/10.2172/5087153" @default.
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