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• W2644175544 abstract "<b><i>Background:</i></b> Huntington disease (HD) is a fatal neurodegenerative disorder involving reduced muscle coordination, mental and behavioral changes, and testicular degeneration. In order to further clarify the decreased fertility and penetration ability of the spermatozoa of transgenic HD minipig boars (TgHD), we applied a set of mitochondrial metabolism (MM) parameter measurements to this promising biological material, which can be collected noninvasively in longitudinal studies. <b><i>Objective:</i></b> We aimed to optimize methods for MM measurements in spermatozoa and to establish possible biomarkers of HD in TgHD spermatozoa expressing the N-terminal part of mutated human huntingtin. <b><i>Methods:</i></b> Semen samples from 12 TgHD and wild-type animals, aged 12-65 months, were obtained repeatedly during the study. Respiration was measured by polarography, MM was assessed by the detection of oxidation of radiolabeled substrates (mitochondrial energy-generating system; MEGS), and the content of the oxidative phosphorylation system subunits was detected by Western blot. Three possibly interfering factors were statistically analyzed: the effect of HD, generation and aging. <b><i>Results:</i></b> We found 5 MM parameters which were significantly diminished in TgHD spermatozoa and propose 3 specific MEGS incubations and complex I-dependent respiration as potential biomarkers of HD in TgHD spermatozoa. <b><i>Conclusions:</i></b> Our results suggest a link between the gain of toxic function of mutated huntingtin in TgHD spermatozoa and the observed MM and/or glycolytic impairment. We determined 4 biomarkers useful for HD phenotyping and experimental therapy monitoring studies in TgHD minipigs." @default.
• W2644175544 created "2017-06-30" @default.
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• W2644175544 date "2017-01-01" @default.
• W2644175544 modified "2023-10-16" @default.
• W2644175544 title "Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs" @default.
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• W2644175544 cites W1870178267 @default.
• W2644175544 cites W1971851525 @default.
• W2644175544 cites W1976338471 @default.
• W2644175544 cites W1982029249 @default.
• W2644175544 cites W1984444180 @default.
• W2644175544 cites W1987050568 @default.
• W2644175544 cites W1987693668 @default.
• W2644175544 cites W1991174366 @default.
• W2644175544 cites W1993978355 @default.
• W2644175544 cites W1997157577 @default.
• W2644175544 cites W2003202110 @default.
• W2644175544 cites W2009362934 @default.
• W2644175544 cites W2010878223 @default.
• W2644175544 cites W2012024892 @default.
• W2644175544 cites W2012539649 @default.
• W2644175544 cites W2015859860 @default.
• W2644175544 cites W2017796669 @default.
• W2644175544 cites W2019042812 @default.
• W2644175544 cites W2022917308 @default.
• W2644175544 cites W2028069007 @default.
• W2644175544 cites W2031280902 @default.
• W2644175544 cites W2053985220 @default.
• W2644175544 cites W2061814167 @default.
• W2644175544 cites W2061927266 @default.
• W2644175544 cites W2062682951 @default.
• W2644175544 cites W2062879575 @default.
• W2644175544 cites W2063062862 @default.
• W2644175544 cites W2064559464 @default.
• W2644175544 cites W2066727251 @default.
• W2644175544 cites W2067662092 @default.
• W2644175544 cites W2068106410 @default.
• W2644175544 cites W2073928850 @default.
• W2644175544 cites W2074521739 @default.
• W2644175544 cites W2082855606 @default.
• W2644175544 cites W2082920621 @default.
• W2644175544 cites W2085101416 @default.
• W2644175544 cites W2085838487 @default.
• W2644175544 cites W2086262648 @default.
• W2644175544 cites W2087704855 @default.
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• W2644175544 cites W2117600112 @default.
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• W2644175544 cites W2157400893 @default.
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• W2644175544 cites W2168364009 @default.
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• W2644175544 cites W2293574512 @default.
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• W2644175544 doi "https://doi.org/10.1159/000475467" @default.
• W2644175544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28633139" @default.
• W2644175544 hasPublicationYear "2017" @default.
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