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- W2644753 abstract "Introduction: The 501 transgenic mice express the transforming T antigen (Tag) of SV40 virus causing spontaneous Tag expression in bone and salivary gland of mice. T ag expression as a self-antigen in osteosarcoma mice leads to progressive loss of CTL responses to T ag epitopes. Objective: 1.To determine the fate of naïve TCR-I cells in tumor bearing osteosarcoma mice that express T antigen as a tumor antigen. 2. The effect of CD40 ligation on the above response. Experiment: T antigen epitope I-specific CD8+ T cells from Tcell receptor transgenic mice (TCR-I cells) were transferred into tumor-bearing 501mice or syngeneic normal C57BL/6 mice. Agonistic anti-CD40 was given day before and day after adoptive transfer(AT), seven days later spleens and cervical lymphnodes, tumors and salivary glands were analyzed for Interferon-γ, epitope-1 specific tetramer, T cell infiltration, and apoptotic TUNEL staining. Results: 1) TCR-I cells expand systemically and acquire effector function 2) Tumor specific CD8+T cell responses are aepitope-I specific. 3) CD40 ligation enhanced TCR-I cell proliferate. 4) In tumor-bearing hosts TCR-I cells proved capable of lysing 100% of target cells in vivo. 5) TCR-I cells infiltrates salivary gland and tumor and enhanced with CD40 ligation. 6) CD40 ligation enhanced anti tumor activity detected by apoptosis using TUNEL. Conclusion: T ag expressed as a tumor antigen in osteosarcomas mice is strongly immunogenic. CD40 ligation enhanced responses to T-ag as measured by TCR-I proliferation, activation, migration into tumors and antitumor cell cytotoxicity." @default.
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- W2644753 date "2008-03-01" @default.
- W2644753 modified "2023-10-18" @default.
- W2644753 title "CD40 Ligation Enhanced Naïve Tumor Antigen Specific CD8+T Cell Responses in Spontaneous Osteosarcoma Model" @default.
- W2644753 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1076.7" @default.
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