FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W26453273> ?p ?o ?g. }

• W26453273 endingPage "42" @default.
• W26453273 startingPage "1" @default.
• W26453273 abstract "Membrane transporters have wide, but specific tissue distributions. They can impact on multiple endogenous and xenobiotic processes. Knowledge and awareness within the pharmaceutical industry of their impact on drug absorption, distribution, metabolism and elimination (ADME) and drug safety is growing rapidly. Clinically important transporter-mediated drug–drug interactions (DDIs) have been observed. Up to nine diverse transporters are implicated in the DDIs of a number of widely prescribed drugs, posing a significant challenge to the pharmaceutical industry. There is a complex interplay between multiple transporters and/or enzymes in the ADME and pharmacogenomics of drugs. Integrating these different mechanisms to understand their relative contributions to ADME is a key challenge. Many different factors complicate the study of membrane transporters in drug development. These include a lack of specific substrates and inhibitors, non-standard in vitro tools, and competing/complementary mechanisms (e.g. passive permeability and metabolism). Discovering and contextualizing the contribution of membrane transporters to drug toxicity is a significant new challenge. Drug interactions with key membrane transporters are routinely assessed for central nervous system (CNS) drug discovery therapies, but are not generally considered across the wider drug discovery. But, there is interest in utilizing membrane transporters as drug delivery agents. Computational modeling approaches, notably physiology-based/pharmacokinetic (PB/PK) modeling are increasingly applied to transporter interactions, and permit integration of multiple ADME mechanisms. Because of the range of tissues and transporters of interest, robust transporter, in vitro to in vivo, scaling factors are required. Empirical factors have been applied, but absolute protein quantitation will probably be required." @default.
• W26453273 created "2016-06-24" @default.
• W26453273 creator A5037449200 @default.
• W26453273 date "2012-01-01" @default.
• W26453273 modified "2023-10-17" @default.
• W26453273 title "Membrane Transporters in Drug Development" @default.
• W26453273 cites W1508816133 @default.
• W26453273 cites W1604547439 @default.
• W26453273 cites W1606416167 @default.
• W26453273 cites W184876112 @default.
• W26453273 cites W1886326176 @default.
• W26453273 cites W1964471078 @default.
• W26453273 cites W1964906039 @default.
• W26453273 cites W1967349297 @default.
• W26453273 cites W1972328515 @default.
• W26453273 cites W1988839609 @default.
• W26453273 cites W1989818377 @default.
• W26453273 cites W1991031764 @default.
• W26453273 cites W1996985091 @default.
• W26453273 cites W1997730952 @default.
• W26453273 cites W2000820979 @default.
• W26453273 cites W2003534761 @default.
• W26453273 cites W2005760784 @default.
• W26453273 cites W2009316291 @default.
• W26453273 cites W2009323095 @default.
• W26453273 cites W2015458748 @default.
• W26453273 cites W2018126221 @default.
• W26453273 cites W2019231695 @default.
• W26453273 cites W2019540147 @default.
• W26453273 cites W2019920149 @default.
• W26453273 cites W2027280333 @default.
• W26453273 cites W2028615902 @default.
• W26453273 cites W2028936105 @default.
• W26453273 cites W2029910949 @default.
• W26453273 cites W2029925799 @default.
• W26453273 cites W2031576029 @default.
• W26453273 cites W2033285446 @default.
• W26453273 cites W2035473648 @default.
• W26453273 cites W2041203878 @default.
• W26453273 cites W2042978696 @default.
• W26453273 cites W2043432548 @default.
• W26453273 cites W2047306923 @default.
• W26453273 cites W2049176537 @default.
• W26453273 cites W2049887617 @default.
• W26453273 cites W2052144043 @default.
• W26453273 cites W2053613516 @default.
• W26453273 cites W2053684254 @default.
• W26453273 cites W2053912143 @default.
• W26453273 cites W2054476033 @default.
• W26453273 cites W2060102878 @default.
• W26453273 cites W2062903328 @default.
• W26453273 cites W2063395237 @default.
• W26453273 cites W2065440110 @default.
• W26453273 cites W2069988713 @default.
• W26453273 cites W2070014315 @default.
• W26453273 cites W2070859235 @default.
• W26453273 cites W2072569486 @default.
• W26453273 cites W2073762710 @default.
• W26453273 cites W2076136110 @default.
• W26453273 cites W2079197876 @default.
• W26453273 cites W2080269820 @default.
• W26453273 cites W2086702076 @default.
• W26453273 cites W2087063957 @default.
• W26453273 cites W2088456604 @default.
• W26453273 cites W2090945850 @default.
• W26453273 cites W2091714925 @default.
• W26453273 cites W2095019580 @default.
• W26453273 cites W2095930613 @default.
• W26453273 cites W2097961663 @default.
• W26453273 cites W2099236176 @default.
• W26453273 cites W2100693452 @default.
• W26453273 cites W2100764580 @default.
• W26453273 cites W2101061694 @default.
• W26453273 cites W2104576211 @default.
• W26453273 cites W2113514190 @default.
• W26453273 cites W2113719939 @default.
• W26453273 cites W2119533770 @default.
• W26453273 cites W2122243774 @default.
• W26453273 cites W2125150734 @default.
• W26453273 cites W2129998904 @default.
• W26453273 cites W2134837921 @default.
• W26453273 cites W2139825215 @default.
• W26453273 cites W2142400726 @default.
• W26453273 cites W2144031452 @default.
• W26453273 cites W2145788371 @default.
• W26453273 cites W2148925220 @default.
• W26453273 cites W2150876331 @default.
• W26453273 cites W2151060548 @default.
• W26453273 cites W2151120582 @default.
• W26453273 cites W2155397673 @default.
• W26453273 cites W2158119880 @default.
• W26453273 cites W2160772283 @default.
• W26453273 cites W2163970210 @default.
• W26453273 cites W2164543086 @default.
• W26453273 cites W2171494430 @default.
• W26453273 cites W2235836043 @default.
• W26453273 cites W2318763909 @default.
• W26453273 cites W2410203350 @default.

• next