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• W264737445 abstract "Publisher Summary This chapter describes how low-dose irradiation has the most detrimental carcinogenic effects in humans. The carcinogenic action of ionizing radiation is clearly demonstrated after exposure to relatively high doses of radiation, but for lower dose levels no reliable direct observations are available. The chapter discusses the concept of stochastic effect, the increased role of molecular biology to obtain insights into mechanisms, the grade of malignancy and the absorbed dose, the types of dose–effect relationships, the relative biological effectiveness of radiation with high linear energy transfer, and the influence of fractionation or protraction of dose on cancer incidence. The techniques of cell culture are essential for identifying the various stages between the initiating event and the eventual emergence of tumorigenic cells. However, analysis and identification of the mutations that lead to activation of oncogenes and inactivation of suppressor genes require investigation of that the tumor." @default.
• W264737445 created "2016-06-24" @default.
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• W264737445 creator A5091271432 @default.
• W264737445 date "1992-01-01" @default.
• W264737445 modified "2023-09-27" @default.
• W264737445 title "Commentary to Fry: Radiation Carcinogenesis Studies in Animals—Advantages, Limitations, and Caveats" @default.
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• W264737445 doi "https://doi.org/10.1016/b978-0-12-035416-0.50014-8" @default.
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