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- W2647803208 abstract "Motor phenotypes of Parkinson's disease (PD) are recognized to have different prognosis and therapeutic response, but the neural basis for this clinical heterogeneity remains largely unknown. The main aim of this study was to compare differences in structural connectivity metrics of the main motor network between tremor-dominant and nontremor PD phenotypes (TD-PD and NT-PD, respectively) using probabilistic tractography-based network analysis. A total of 63 PD patients (35 TD-PD patients and 28 NT-PD patients) and 30 healthy controls underwent a 3 T MRI. Next, probabilistic tractography-based network analysis was performed to assess structural connectivity in cerebello-thalamo-basal ganglia-cortical circuits, by measuring the connectivity indices of each tract and the efficiency of each node. Furthermore, dopamine transporter single-photon emission computed tomography (DAT-SPECT) with 123 I-ioflupane was used to assess dopaminergic striatal depletion in all PD patients. Both PD phenotypes showed nodal abnormalities in the substantia nigra, in agreement with DAT-SPECT evaluation. In addition, NT-PD patients displayed connectivity alterations in nigro-pallidal and fronto-striatal pathways, compared with both controls and TD-PD patients, in which the same motor connections seemed to be relatively spared. Of note, in NT-PD group, rigidity-bradykinesia score correlated with fronto-striatal connectivity abnormalities. These findings demonstrate that structural connectivity alterations occur in the cortico-basal ganglia circuit of NT-PD patients, but not in TD-PD patients, suggesting that these anatomical differences may underlie different motor phenotypes of PD. Hum Brain Mapp 38:4716-4729, 2017. © 2017 Wiley Periodicals, Inc." @default.
- W2647803208 created "2017-06-30" @default.
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- W2647803208 date "2017-06-20" @default.
- W2647803208 modified "2023-10-17" @default.
- W2647803208 title "Structural connectivity differences in motor network between tremor-dominant and nontremor Parkinson's disease" @default.
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- W2647803208 cites W1847168837 @default.
- W2647803208 cites W1943131318 @default.
- W2647803208 cites W1963735224 @default.
- W2647803208 cites W1969895941 @default.
- W2647803208 cites W1974038177 @default.
- W2647803208 cites W1974764791 @default.
- W2647803208 cites W1976536148 @default.
- W2647803208 cites W1977586101 @default.
- W2647803208 cites W1984414718 @default.
- W2647803208 cites W1997362287 @default.
- W2647803208 cites W1998587902 @default.
- W2647803208 cites W1999653836 @default.
- W2647803208 cites W2000133863 @default.
- W2647803208 cites W2002425106 @default.
- W2647803208 cites W2008560062 @default.
- W2647803208 cites W2008854521 @default.
- W2647803208 cites W2010865726 @default.
- W2647803208 cites W2016944352 @default.
- W2647803208 cites W2021834292 @default.
- W2647803208 cites W2025429003 @default.
- W2647803208 cites W2026344793 @default.
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- W2647803208 cites W2034574202 @default.
- W2647803208 cites W2045716619 @default.
- W2647803208 cites W2058007888 @default.
- W2647803208 cites W2058161128 @default.
- W2647803208 cites W2064963539 @default.
- W2647803208 cites W2064996887 @default.
- W2647803208 cites W2067726982 @default.
- W2647803208 cites W2069743462 @default.
- W2647803208 cites W2072797584 @default.
- W2647803208 cites W2083565078 @default.
- W2647803208 cites W2086701255 @default.
- W2647803208 cites W2087565659 @default.
- W2647803208 cites W2089085990 @default.
- W2647803208 cites W2089858495 @default.
- W2647803208 cites W2089940272 @default.
- W2647803208 cites W2090337748 @default.
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- W2647803208 cites W2101805339 @default.
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- W2647803208 cites W2115116088 @default.
- W2647803208 cites W2119983331 @default.
- W2647803208 cites W2128456781 @default.
- W2647803208 cites W2128820615 @default.
- W2647803208 cites W2130974692 @default.
- W2647803208 cites W2142059961 @default.
- W2647803208 cites W2145039080 @default.
- W2647803208 cites W2146552439 @default.
- W2647803208 cites W2148080316 @default.
- W2647803208 cites W2149439832 @default.
- W2647803208 cites W2156281013 @default.
- W2647803208 cites W2158900973 @default.
- W2647803208 cites W2162559061 @default.
- W2647803208 cites W2166524215 @default.
- W2647803208 cites W2167311298 @default.
- W2647803208 cites W2222869326 @default.
- W2647803208 cites W2225695071 @default.
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- W2647803208 cites W2355160806 @default.
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- W2647803208 doi "https://doi.org/10.1002/hbm.23697" @default.
- W2647803208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6866900" @default.
- W2647803208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28631404" @default.
- W2647803208 hasPublicationYear "2017" @default.
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