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- W2648146297 abstract "Approximately one-third of all neuropsychiatric (NP) syndromes in SLE patients are primary manifestations of lupus autoimmunity. Seizure disorders, cerebrovascular disease, acute confusional states, and neuropathies are the most common. Primary NP lupus (NPSLE) events are a consequence of either mircrovasculopathy and thrombosis or autoantibodies and inflammatory mediators. The diagnosis of NPSLE requires the exclusion of other causes and the clinical assessment directs the selection of appropriate investigations. These include measurement of autoantibodies, analysis of cerebrospinal fluid, electrophysiological studies, neuropsychological assessment, and neuroimaging to evaluate brain structure and function. Treatment should include the management of comorbidities contributing to the NP event, use of symptomatic therapies, and more specific interventions with either anticoagulation or immunosuppressive agents, depending on the primary immunopathogenetic mechanism. Although the prognosis is variable, recent studies suggest a more favorable outcome for primary NPSLE manifestations compared to NP events attributed to non-SLE causes." @default.
- W2648146297 created "2017-06-30" @default.
- W2648146297 creator A5041711237 @default.
- W2648146297 date "2016-01-01" @default.
- W2648146297 modified "2023-09-23" @default.
- W2648146297 title "The Nervous System in Systemic Lupus Erythematosus" @default.
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- W2648146297 doi "https://doi.org/10.1016/b978-0-12-801917-7.00047-4" @default.
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