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- W2648308082 abstract "The proliferation of new psychoactive substances (NPS) in recent years has resulted in the development of numerous analytical methods for the detection and identification of known and unknown NPS derivatives. High-resolution mass spectrometry (HRMS) has been identified as the method of choice for broad screening of NPS in a wide range of analytical contexts because of its ability to measure accurate masses using data-independent acquisition (DIA) techniques. Additionally, it has shown promise for non-targeted screening strategies that have been developed in order to detect and identify novel analogues without the need for certified reference materials (CRMs) or comprehensive mass spectral libraries. This paper reviews the applications of HRMS for the analysis of NPS in forensic drug chemistry and analytical toxicology. It provides an overview of the sample preparation procedures in addition to data acquisition, instrumental analysis, and data processing techniques. Furthermore, it gives an overview of the current state of non-targeted screening strategies with discussion on future directions and perspectives of this technique. Graphical Abstract Missing the bullseye - a graphical respresentation of non-targeted screening. Image courtesy of Christian Alonzo." @default.
- W2648308082 created "2017-06-30" @default.
- W2648308082 creator A5014938994 @default.
- W2648308082 creator A5023012772 @default.
- W2648308082 creator A5048646754 @default.
- W2648308082 creator A5054111036 @default.
- W2648308082 date "2017-06-20" @default.
- W2648308082 modified "2023-10-18" @default.
- W2648308082 title "Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review" @default.
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