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- W26483688 abstract "Gas exchange in any tissue or organ requires O2 delivery (and CO2 removal) along a transport pathway involving, sequentially, the lungs, heart, blood, circulation, and tissues. Convective factors governed mostly by the lungs, heart, blood, and circulation determine how much O2 reaches each tissue, while diffusion underlies tissue O2 unloading and transport to mitochondria. O2 consumption may be limited by these transport processes, or alternatively may be set by tissue metabolic demand. The maximal amount of O2 available to mitochondria is not determined uniquely by any one step in the transport pathway, but by all in an integrated manner. Because the pathway steps are arranged in series, poor function of any single step significantly reduces maximal O2 transport, while greater than normal function of any such step increases overall transport only slightly. When considering central and peripheral limitations to O2 transport, it is evident that convective O2 delivery to tissues depends in part on peripheral factors (regional vascular conductances), while diffusive unloading in the periphery depends in part on central factors (especially blood flow). In both health and disease, central and peripheral factors contribute to limitations on O2 transport, at least in the area of muscle function during exercise, where the O2 transport system is often stretched to its limits." @default.
- W26483688 created "2016-06-24" @default.
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- W26483688 date "2006-01-01" @default.
- W26483688 modified "2023-10-16" @default.
- W26483688 title "PERIPHERAL GAS EXCHANGE" @default.
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- W26483688 doi "https://doi.org/10.1016/b0-12-370879-6/00159-9" @default.
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