FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2648511035> ?p ?o ?g. }

• W2648511035 endingPage "497" @default.
• W2648511035 startingPage "481" @default.
• W2648511035 abstract "ABSTRACT Genome‐wide association studies (GWASs) commonly use marginal association tests for each single‐nucleotide polymorphism (SNP). Because these tests treat SNPs as independent, their power will be suboptimal for detecting SNPs hidden by linkage disequilibrium (LD). One way to improve power is to use a multiple regression model. However, the large number of SNPs preclude simultaneous fitting with multiple regression, and subset regression is infeasible because of an exorbitant number of candidate subsets. We therefore propose a new method for detecting hidden SNPs having significant yet weak marginal association in a multiple regression model. Our method begins by constructing a bidirected graph locally around each SNP that demonstrates a moderately sized marginal association signal, the focal SNPs. Vertexes correspond to SNPs, and adjacency between vertexes is defined by an LD measure. Subsequently, the method collects from each graph all shortest paths to the focal SNP. Finally, for each shortest path the method fits a multiple regression model to all the SNPs lying in the path and tests the significance of the regression coefficient corresponding to the terminal SNP in the path. Simulation studies show that the proposed method can detect susceptibility SNPs hidden by LD that go undetected with marginal association testing or with existing multivariate methods. When applied to real GWAS data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), our method detected two groups of SNPs: one in a region containing the apolipoprotein E ( APOE ) gene, and another in a region close to the semaphorin 5A ( SEMA5A ) gene." @default.
• W2648511035 created "2017-06-30" @default.
• W2648511035 creator A5025131575 @default.
• W2648511035 creator A5055963311 @default.
• W2648511035 creator A5075718612 @default.
• W2648511035 creator A5088633583 @default.
• W2648511035 date "2017-06-19" @default.
• W2648511035 modified "2023-10-14" @default.
• W2648511035 title "Detecting genetic association through shortest paths in a bidirected graph" @default.
• W2648511035 cites W1606340441 @default.
• W2648511035 cites W1971220718 @default.
• W2648511035 cites W1978124765 @default.
• W2648511035 cites W1978359174 @default.
• W2648511035 cites W1980991473 @default.
• W2648511035 cites W1989373272 @default.
• W2648511035 cites W1999545910 @default.
• W2648511035 cites W2003668169 @default.
• W2648511035 cites W2005935256 @default.
• W2648511035 cites W2024834494 @default.
• W2648511035 cites W2029220352 @default.
• W2648511035 cites W2046659207 @default.
• W2648511035 cites W2063978378 @default.
• W2648511035 cites W2070082005 @default.
• W2648511035 cites W2075816992 @default.
• W2648511035 cites W2078171863 @default.
• W2648511035 cites W2082791523 @default.
• W2648511035 cites W2097360283 @default.
• W2648511035 cites W2099623594 @default.
• W2648511035 cites W2102381029 @default.
• W2648511035 cites W2104570606 @default.
• W2648511035 cites W2112051837 @default.
• W2648511035 cites W2119841530 @default.
• W2648511035 cites W2122066039 @default.
• W2648511035 cites W2139647754 @default.
• W2648511035 cites W2155635136 @default.
• W2648511035 cites W2160231421 @default.
• W2648511035 cites W2161633633 @default.
• W2648511035 cites W4294541781 @default.
• W2648511035 doi "https://doi.org/10.1002/gepi.22051" @default.
• W2648511035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5849262" @default.
• W2648511035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28626864" @default.
• W2648511035 hasPublicationYear "2017" @default.
• W2648511035 type Work @default.
• W2648511035 sameAs 2648511035 @default.
• W2648511035 citedByCount "4" @default.
• W2648511035 countsByYear W26485110352019 @default.
• W2648511035 countsByYear W26485110352021 @default.
• W2648511035 crossrefType "journal-article" @default.
• W2648511035 hasAuthorship W2648511035A5025131575 @default.
• W2648511035 hasAuthorship W2648511035A5055963311 @default.
• W2648511035 hasAuthorship W2648511035A5075718612 @default.
• W2648511035 hasAuthorship W2648511035A5088633583 @default.
• W2648511035 hasBestOaLocation W26485110351 @default.
• W2648511035 hasConcept C104317684 @default.
• W2648511035 hasConcept C105795698 @default.
• W2648511035 hasConcept C106208931 @default.
• W2648511035 hasConcept C135763542 @default.
• W2648511035 hasConcept C139275648 @default.
• W2648511035 hasConcept C153209595 @default.
• W2648511035 hasConcept C186413461 @default.
• W2648511035 hasConcept C33923547 @default.
• W2648511035 hasConcept C35605836 @default.
• W2648511035 hasConcept C54355233 @default.
• W2648511035 hasConcept C83546350 @default.
• W2648511035 hasConcept C86803240 @default.
• W2648511035 hasConceptScore W2648511035C104317684 @default.
• W2648511035 hasConceptScore W2648511035C105795698 @default.
• W2648511035 hasConceptScore W2648511035C106208931 @default.
• W2648511035 hasConceptScore W2648511035C135763542 @default.
• W2648511035 hasConceptScore W2648511035C139275648 @default.
• W2648511035 hasConceptScore W2648511035C153209595 @default.
• W2648511035 hasConceptScore W2648511035C186413461 @default.
• W2648511035 hasConceptScore W2648511035C33923547 @default.
• W2648511035 hasConceptScore W2648511035C35605836 @default.
• W2648511035 hasConceptScore W2648511035C54355233 @default.
• W2648511035 hasConceptScore W2648511035C83546350 @default.
• W2648511035 hasConceptScore W2648511035C86803240 @default.
• W2648511035 hasFunder F4320306080 @default.
• W2648511035 hasFunder F4320306219 @default.
• W2648511035 hasFunder F4320307115 @default.
• W2648511035 hasFunder F4320307132 @default.
• W2648511035 hasFunder F4320307765 @default.
• W2648511035 hasFunder F4320307776 @default.
• W2648511035 hasFunder F4320308604 @default.
• W2648511035 hasFunder F4320309117 @default.
• W2648511035 hasFunder F4320309432 @default.
• W2648511035 hasFunder F4320309470 @default.
• W2648511035 hasFunder F4320309697 @default.
• W2648511035 hasFunder F4320310045 @default.
• W2648511035 hasFunder F4320310388 @default.
• W2648511035 hasFunder F4320310465 @default.
• W2648511035 hasFunder F4320311551 @default.
• W2648511035 hasFunder F4320323095 @default.
• W2648511035 hasFunder F4320332161 @default.
• W2648511035 hasFunder F4320332193 @default.
• W2648511035 hasFunder F4320332457 @default.
• W2648511035 hasFunder F4320334506 @default.
• W2648511035 hasFunder F4320334764 @default.

• next