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• W2649063040 endingPage "2154" @default.
• W2649063040 startingPage "2144" @default.
• W2649063040 abstract "Chronic alcohol use is associated with lower gray matter volume, and we reported recently that alcohol use showed negative associations with widespread gray matter (GM) volume even among young adults. The current study aimed to test the strength of association between (1) alcohol use and GM volume; (2) alcohol use and white matter (WM) integrity; (3) cannabis use and GM volume; and (4) cannabis use and WM integrity among adults and adolescents.General linear models within large pooled cross-sectional samples of adolescents and adults who had participated in studies collecting substance use and neuroimaging data in the southwestern United States.The current analysis included adults aged 18-55 years (n = 853) and adolescents aged 14-18 years (n = 439) with a range of alcohol and cannabis use.The dependent variable was GM volume or WM integrity, with key predictors of alcohol use [Alcohol Use Disorders Identification Test (AUDIT) score] and cannabis use (past 30-day use).Alcohol use showed large clusters of negative associations (ηp2 = 0.028-0.145, P < 0.001) with GM volume among adults and to a lesser extent (one cluster; ηp2 = 0.070, P < 0.05) among adolescents. Large clusters showed significant associations (ηp2 = 0.050-0.124, P < 0.001) of higher alcohol use with poorer WM integrity, whereas adolescents showed no significant associations between alcohol use and WM. No associations were observed between structural measures and past 30-day cannabis use in adults or adolescents.Alcohol use severity is associated with widespread lower gray matter volume and white matter integrity in adults, and with lower gray matter volume in adolescents." @default.
• W2649063040 created "2017-06-30" @default.
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• W2649063040 date "2017-08-01" @default.
• W2649063040 modified "2023-10-15" @default.
• W2649063040 title "Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults" @default.
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• W2649063040 doi "https://doi.org/10.1111/add.13923" @default.
• W2649063040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5673530" @default.
• W2649063040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28646566" @default.
• W2649063040 hasPublicationYear "2017" @default.
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