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• W2649791421 endingPage "2847" @default.
• W2649791421 startingPage "2839" @default.
• W2649791421 abstract "In cell therapies, it is advantageous to encapsulate live cells in protective, semipermeable microparticles for controlled release of cytokines, growth factors, monoclonal antibodies, or insulin. Here, a modified electrospraying approach with an organic solution of poly(lactide-co-glycolide) (PLGA) polymer is used to create synthetic PLGA capsules that effectively protect live cells. Using a design of experiment (DOE) methodology, the effect of governing jetting parameters on encapsulation efficiency, yield, and size is systematically evaluated. On the basis of this analysis, the interaction between bovine serum albumin concentration and core flow rate is the most dominant factor determining core encapsulation efficiency as well as the microcapsule size. However, the interaction between shell solvent ratio and shell flow rate predominantly defines the particle yield. To validate these findings, live cells have been successfully encapsulated in microcapsules using optimized parameters from the DOE analysis and have survived the electrohydrodynamic jetting process. Extending the currently available toolkit for cell microencapsulation, these biodegradable, semi-impermeable cell-laden microcapsules may find a range of applications in areas such as tissue engineering, regenerative medicine, and drug delivery." @default.
• W2649791421 created "2017-06-30" @default.
• W2649791421 creator A5000941459 @default.
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• W2649791421 date "2017-06-21" @default.
• W2649791421 modified "2023-10-16" @default.
• W2649791421 title "Microencapsulation of Live Cells in Synthetic Polymer Capsules" @default.
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• W2649791421 doi "https://doi.org/10.1021/acsomega.7b00570" @default.
• W2649791421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6044854" @default.
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• W2649791421 hasPublicationYear "2017" @default.
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