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- W26499124 abstract "This chapter discusses an experiment to study the effects of structural analogs and drugs on hypotaurine uptake in brain slices. In the experiment, the properties of hypotaurine uptake were characterized by incubating mouse brain slices for 15 min at 310 K under O2 in Krebs–Ringer–HEPES–glucose medium (pH 7.4) with varying amounts of [35S]-hypotaurine and in the presence of several structural analogs and centrally acting drugs. Hypotaurine uptake was most strongly inhibited by GABA, L-DABA, β-alanine, and cysteic acid, particularly at low hypotaurine concentrations. Glycine, cysteine, cystamine, cysteine sulfinic acid, and taurine had only a moderate effect, whereas methionine sulfoxide, isethionic acid, amidosulfonic acid, and N-methyltaurine had no apparent effect. In the presence of GABA or β-alanine, the high-affinity uptake of hypotaurine was completely blocked and the low-affinity uptake inhibited to a lesser degree. Cysteic acid inhibited only the low-affinity transport component without affecting the high-affinity uptake. Chlorpromazine almost abolished hypotaurine uptake. It was found that certain antiepileptic drugs tend to inhibit hypotaurine uptake, whereas carbamazepine, ethosuximide, sultiame, and clonazepam had no effect. The results indicated a rather specific transport system for hypotaurine in which GABA and its structural analogs, however, act as fairly strong inhibitors." @default.
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- W26499124 date "1980-01-01" @default.
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- W26499124 title "EFFECTS OF STRUCTURAL ANALOGUES AND DRUGS ON HYPOTAURINE UPTAKE IN BRAIN SLICES" @default.
- W26499124 doi "https://doi.org/10.1016/b978-0-08-025921-5.50031-x" @default.
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