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- W2650773579 abstract "Abstract Positioning of nucleosomes along the genomic DNA is crucial for many cellular processes that include gene regulation and higher order packaging of chromatin. The question of how nucleosome-positioning information from a parent chromatin gets transferred to the daughter chromatin is highly intriguing. Accounting for experimentally known coupling between replisome movement and nucleosome dynamics, we propose a model that can explain the inheritance of nucleosome positioning. Simulating nucleosome dynamics during replication we argue that short pausing of the replication fork, associated with nucleosome disassembly, can be the event crucial for communicating nucleosome positioning information from parent to daughter. We show that the interplay of timescales between nucleosome disassembly ( τ p ) at the replication fork and nucleosome sliding behind the fork ( τ s ) can give rise to a rich “phase diagram” having different inherited patterns of nucleosome organization. Our model predicts that only when τ p ≥ τ s the daughter chromatin can inherit the precise nucleosome positioning of the parent." @default.
- W2650773579 created "2017-06-30" @default.
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- W2650773579 date "2017-06-23" @default.
- W2650773579 modified "2023-09-26" @default.
- W2650773579 title "Coupling of replisome movement with nucleosome dynamics can contribute to the parent-daughter information transfer" @default.
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- W2650773579 doi "https://doi.org/10.1101/154559" @default.
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