Matches in SemOpenAlex for { <https://semopenalex.org/work/W2652072637> ?p ?o ?g. }
- W2652072637 abstract "Disturbances in intrinsic activity during resting-state functional MRI (rsfMRI) are common in Parkinson’s disease (PD), but have largely been studied in a priori defined subnetworks. The cognitive significance of abnormal intrinsic activity is also poorly understood, as are abnormalities that precede the onset of mild cognitive impairment. To address these limitations, we leveraged three different analytic approaches to identify disturbances in rsfMRI metrics in 31 cognitively normal PD patients (PD-CN) and 30 healthy adults. Subjects were screened for mild cognitive impairment using the Movement Disorders Society Task Force Level II criteria. Whole-brain data-driven analytic approaches first analyzed the amplitude of low-frequency intrinsic fluctuations (ALFF) and regional homogeneity (ReHo), a measure of local connectivity amongst functionally similar regions. We then examined if regional disturbances in these metrics altered functional connectivity with other brain regions. We also investigated if abnormal rsfMRI metrics in PD-CN were related to brain atrophy and executive, visual organization, and episodic memory functioning. The results revealed abnormally increased and decreased ALFF and ReHo in PD-CN patients within the default mode network (posterior cingulate, inferior parietal cortex, parahippocampus, entorhinal cortex), sensorimotor cortex (primary motor, pre/postcentral gyrus), basal ganglia (putamen, caudate), and posterior cerebellar lobule VII, which mediates cognition. For default mode network regions, we also observed a compound profile of altered ALFF and ReHo. Most regional disturbances in ALFF and ReHo were associated with strengthened long-range interactions in PD-CN, notably with regions in different networks. Stronger long-range functional connectivity in PD-CN was also partly expanded to connections that were outside the networks of the control group. Abnormally increased activity and functional connectivity appeared to have a pathological, rather than compensatory influence on cognitive abilities tested in this study. Receiver operating curve analyses demonstrated excellent sensitivity (≥ 90%) of rsfMRI variables in distinguishing patients from controls, but poor accuracy for brain volume and cognitive variables. Altogether these results provide new insights into the topology, cognitive relevance, and sensitivity of aberrant intrinsic activity and connectivity that precedes clinically significant cognitive impairment. Longitudinal studies are needed to determine if these neurocognitive associations presage the development of future mild cognitive impairment or dementia." @default.
- W2652072637 created "2017-06-30" @default.
- W2652072637 creator A5006709022 @default.
- W2652072637 creator A5035771186 @default.
- W2652072637 creator A5039966808 @default.
- W2652072637 creator A5042942606 @default.
- W2652072637 creator A5047687919 @default.
- W2652072637 creator A5059531671 @default.
- W2652072637 creator A5080242253 @default.
- W2652072637 date "2017-06-19" @default.
- W2652072637 modified "2023-10-10" @default.
- W2652072637 title "Aberrant Intrinsic Activity and Connectivity in Cognitively Normal Parkinson’s Disease" @default.
- W2652072637 cites W1491640814 @default.
- W2652072637 cites W1534845677 @default.
- W2652072637 cites W1795009050 @default.
- W2652072637 cites W1908041793 @default.
- W2652072637 cites W1915104755 @default.
- W2652072637 cites W1925238593 @default.
- W2652072637 cites W1953595492 @default.
- W2652072637 cites W1971899546 @default.
- W2652072637 cites W1972010893 @default.
- W2652072637 cites W1977761644 @default.
- W2652072637 cites W1980527160 @default.
- W2652072637 cites W1980742191 @default.
- W2652072637 cites W1981873383 @default.
- W2652072637 cites W1985476929 @default.
- W2652072637 cites W1986398237 @default.
- W2652072637 cites W1986724788 @default.
- W2652072637 cites W1988628854 @default.
- W2652072637 cites W1994152822 @default.
- W2652072637 cites W1997147102 @default.
- W2652072637 cites W1997230335 @default.
- W2652072637 cites W1999897000 @default.
- W2652072637 cites W2003638135 @default.
- W2652072637 cites W2007213925 @default.
- W2652072637 cites W2023390230 @default.
- W2652072637 cites W2027056518 @default.
- W2652072637 cites W2027346623 @default.
- W2652072637 cites W2028611286 @default.
- W2652072637 cites W2029132563 @default.
- W2652072637 cites W2030488859 @default.
- W2652072637 cites W2038618926 @default.
- W2652072637 cites W2042824095 @default.
- W2652072637 cites W2056288823 @default.
- W2652072637 cites W2056620530 @default.
- W2652072637 cites W2060523616 @default.
- W2652072637 cites W2061176259 @default.
- W2652072637 cites W2063976700 @default.
- W2652072637 cites W2067726982 @default.
- W2652072637 cites W2067808181 @default.
- W2652072637 cites W2068275821 @default.
- W2652072637 cites W2070450901 @default.
- W2652072637 cites W2073690998 @default.
- W2652072637 cites W2073972018 @default.
- W2652072637 cites W2075079864 @default.
- W2652072637 cites W2078563124 @default.
- W2652072637 cites W2089085990 @default.
- W2652072637 cites W2090572137 @default.
- W2652072637 cites W2101850447 @default.
- W2652072637 cites W2102113123 @default.
- W2652072637 cites W2104016179 @default.
- W2652072637 cites W2104650622 @default.
- W2652072637 cites W2104679634 @default.
- W2652072637 cites W2106507629 @default.
- W2652072637 cites W2116949073 @default.
- W2652072637 cites W2123886317 @default.
- W2652072637 cites W2125821516 @default.
- W2652072637 cites W2125868297 @default.
- W2652072637 cites W2126728600 @default.
- W2652072637 cites W2128443648 @default.
- W2652072637 cites W2129697505 @default.
- W2652072637 cites W2131881760 @default.
- W2652072637 cites W2132827635 @default.
- W2652072637 cites W2134729310 @default.
- W2652072637 cites W2136963578 @default.
- W2652072637 cites W2143346651 @default.
- W2652072637 cites W2144623340 @default.
- W2652072637 cites W2149431833 @default.
- W2652072637 cites W2150525160 @default.
- W2652072637 cites W2152837663 @default.
- W2652072637 cites W2156013560 @default.
- W2652072637 cites W2157795677 @default.
- W2652072637 cites W2186798389 @default.
- W2652072637 cites W2220139753 @default.
- W2652072637 cites W2257742328 @default.
- W2652072637 cites W2279759292 @default.
- W2652072637 cites W2293685131 @default.
- W2652072637 cites W2413907949 @default.
- W2652072637 cites W2438488172 @default.
- W2652072637 cites W2462033511 @default.
- W2652072637 cites W2468548174 @default.
- W2652072637 cites W2486493418 @default.
- W2652072637 cites W2519960383 @default.
- W2652072637 cites W2573434971 @default.
- W2652072637 doi "https://doi.org/10.3389/fnagi.2017.00197" @default.
- W2652072637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5474556" @default.
- W2652072637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28674492" @default.
- W2652072637 hasPublicationYear "2017" @default.
- W2652072637 type Work @default.
- W2652072637 sameAs 2652072637 @default.