FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2653668500> ?p ?o ?g. }

• W2653668500 endingPage "1350" @default.
• W2653668500 startingPage "1342" @default.
• W2653668500 abstract "Lipid homoeostasis is disturbed in patients with HCV infection. Direct-acting antiviral agent (DAA) treatment eradicates chronic HCV viraemia, but the dynamics of lipid components remain elusive. This study investigates the clinical manifestation and mechanistic relevance of plasma triglyceride (TG), cholesterol (Chol), lipoproteins and apolipoproteins (apos) after DAA treatment.Twenty-four patients with chronic genotype 1 (GT1) HCV treated with elbasvir/grazoprevir or ledipasvir/sofosbuvir for 12 weeks, and followed-up thereafter, were recruited. Their TG, Chol, apoAI and apoB levels were quantified in plasma samples and individually fractionated lipoprotein of various classes. Liver fibrosis was evaluated using the FIB-4 Score. The TG and Chol loading capacities were calculated with normalisation to apoB, which represents per very low density lipoprotein (VLDL) and LDL particle unit RESULTS: DAA treatment achieved a sustained virological response rate of 91.7% and reduced the FIB-4 Score. Relative to the baseline, the plasma TG level was reduced but the Chol level increased gradually. Plasma apoB levels and apoB/apoAI ratio were transiently downregulated as early as the first 4 weeks of treatment. The TG and Chol loading capacities in VLDL were elevated by ~20% during the period of DAA treatment and had steadily increased by 100% at follow-up. Furthermore, the TG-to-Chol ratio in VLDL was increased, while the ratio in LDL was reduced, indicating an efficient catabolism.The DAA treatment of patients with chronic hepatitis C might lead to efficient HCV eradication and hepatic improvement concomitantly evolving with favouring lipoprotein/apo metabolisms." @default.
• W2653668500 created "2017-06-30" @default.
• W2653668500 creator A5024278939 @default.
• W2653668500 creator A5025004801 @default.
• W2653668500 creator A5054156847 @default.
• W2653668500 creator A5082993634 @default.
• W2653668500 creator A5084781631 @default.
• W2653668500 creator A5064999048 @default.
• W2653668500 date "2017-06-14" @default.
• W2653668500 modified "2023-10-17" @default.
• W2653668500 title "Favouring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic HCV infection" @default.
• W2653668500 cites W1259128932 @default.
• W2653668500 cites W1488236888 @default.
• W2653668500 cites W1496308625 @default.
• W2653668500 cites W1977300462 @default.
• W2653668500 cites W1978436940 @default.
• W2653668500 cites W1994501461 @default.
• W2653668500 cites W2000307707 @default.
• W2653668500 cites W2000789033 @default.
• W2653668500 cites W2002461132 @default.
• W2653668500 cites W2007013372 @default.
• W2653668500 cites W2010509924 @default.
• W2653668500 cites W2013018952 @default.
• W2653668500 cites W2022396880 @default.
• W2653668500 cites W2028350152 @default.
• W2653668500 cites W2036306822 @default.
• W2653668500 cites W2046449500 @default.
• W2653668500 cites W2049520707 @default.
• W2653668500 cites W2051984446 @default.
• W2653668500 cites W2053716682 @default.
• W2653668500 cites W2057967679 @default.
• W2653668500 cites W2061632860 @default.
• W2653668500 cites W2062312682 @default.
• W2653668500 cites W2065381342 @default.
• W2653668500 cites W2078364031 @default.
• W2653668500 cites W2082842671 @default.
• W2653668500 cites W2087716056 @default.
• W2653668500 cites W2088337379 @default.
• W2653668500 cites W2088337621 @default.
• W2653668500 cites W2090825777 @default.
• W2653668500 cites W2094733152 @default.
• W2653668500 cites W2095612977 @default.
• W2653668500 cites W2105291849 @default.
• W2653668500 cites W2109909051 @default.
• W2653668500 cites W2120165528 @default.
• W2653668500 cites W2127274349 @default.
• W2653668500 cites W2128977054 @default.
• W2653668500 cites W2140936726 @default.
• W2653668500 cites W2141769755 @default.
• W2653668500 cites W2144449254 @default.
• W2653668500 cites W2147182282 @default.
• W2653668500 cites W2152112546 @default.
• W2653668500 cites W2160425277 @default.
• W2653668500 cites W2162470776 @default.
• W2653668500 cites W2166330175 @default.
• W2653668500 cites W2166580125 @default.
• W2653668500 cites W2175038046 @default.
• W2653668500 cites W2285312163 @default.
• W2653668500 cites W2398637919 @default.
• W2653668500 cites W2404156343 @default.
• W2653668500 cites W2580756510 @default.
• W2653668500 doi "https://doi.org/10.1136/gutjnl-2017-313832" @default.
• W2653668500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28615303" @default.
• W2653668500 hasPublicationYear "2017" @default.
• W2653668500 type Work @default.
• W2653668500 sameAs 2653668500 @default.
• W2653668500 citedByCount "23" @default.
• W2653668500 countsByYear W26536685002017 @default.
• W2653668500 countsByYear W26536685002018 @default.
• W2653668500 countsByYear W26536685002019 @default.
• W2653668500 countsByYear W26536685002020 @default.
• W2653668500 countsByYear W26536685002021 @default.
• W2653668500 countsByYear W26536685002022 @default.
• W2653668500 countsByYear W26536685002023 @default.
• W2653668500 crossrefType "journal-article" @default.
• W2653668500 hasAuthorship W2653668500A5024278939 @default.
• W2653668500 hasAuthorship W2653668500A5025004801 @default.
• W2653668500 hasAuthorship W2653668500A5054156847 @default.
• W2653668500 hasAuthorship W2653668500A5064999048 @default.
• W2653668500 hasAuthorship W2653668500A5082993634 @default.
• W2653668500 hasAuthorship W2653668500A5084781631 @default.
• W2653668500 hasConcept C126322002 @default.
• W2653668500 hasConcept C134018914 @default.
• W2653668500 hasConcept C203014093 @default.
• W2653668500 hasConcept C2522874641 @default.
• W2653668500 hasConcept C2775999097 @default.
• W2653668500 hasConcept C2776408679 @default.
• W2653668500 hasConcept C2776979040 @default.
• W2653668500 hasConcept C2778096610 @default.
• W2653668500 hasConcept C2778163477 @default.
• W2653668500 hasConcept C2778390639 @default.
• W2653668500 hasConcept C2778913445 @default.
• W2653668500 hasConcept C2780040827 @default.
• W2653668500 hasConcept C2780072125 @default.
• W2653668500 hasConcept C511355011 @default.
• W2653668500 hasConcept C62746215 @default.
• W2653668500 hasConcept C71924100 @default.
• W2653668500 hasConcept C8243546 @default.

• next