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- W2656875265 abstract "Significance Innate immunity provides critical defense against pathogen invasion, and mutations in its cellular mechanisms have been implicated in autoimmunity, immune suppression, and other disease-producing conditions. However, knowledge of innate immunity pathways is largely biased toward model species. Thus, evolutionary interpretations suffer from large taxonomic gaps that ultimately weaken the strength of evolutionary inference. Our phylogenetic approach shows that the molecular machinery of the canonical TLR pathway was present in the last deuterostome ancestor before the rise of chordate lineages. Thus, TLR pathways with multiple gene–gene interactions have been conserved for more than 500 million years within vertebrates. Moreover, we provide evidence suggesting TLR3 may represent an ancient, evolutionarily conserved molecular interface for viral immune stimulation present across Deuterostomia." @default.
- W2656875265 created "2017-06-30" @default.
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- W2656875265 date "2017-06-19" @default.
- W2656875265 modified "2023-10-12" @default.
- W2656875265 title "Toll-like receptor pathway evolution in deuterostomes" @default.
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- W2656875265 doi "https://doi.org/10.1073/pnas.1617722114" @default.
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