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- W2657486574 endingPage "499" @default.
- W2657486574 startingPage "486" @default.
- W2657486574 abstract "Plants belonging to the Amaryllidaceae family are well known for their ornamental and medicinal use. Plant members of this group are distributed through both tropical and subtropical regions of the world and are dominant in Andean South America, the Mediterranean basin, and southern Africa. Amaryllidaceae plants have been demonstrated to be a good source of alkaloids with a large spectrum of biological activities, the latter being strictly related to the absolute stereochemistry of the alkaloid scaffold. Among them, great importance for practical applications in medicine has galanthamine, which has already spawned an Alzheimer's prescription drug as a potent and selective inhibitor of the enzyme acetylcholinesterase. Furthermore, lycorine as well as its related isocarbostyryl analogs narciclasine and pancratistatine have shown a strong anticancer activity in vitro against different solid tumors with malignant prognosis. This review addresses the assignment of the absolute configuration of several Amaryllidaceae alkaloids and its relationship with their biological activities." @default.
- W2657486574 created "2017-06-30" @default.
- W2657486574 creator A5037233387 @default.
- W2657486574 creator A5052002042 @default.
- W2657486574 creator A5063443142 @default.
- W2657486574 creator A5070848652 @default.
- W2657486574 date "2017-06-26" @default.
- W2657486574 modified "2023-10-16" @default.
- W2657486574 title "Amaryllidaceae alkaloids: Absolute configuration and biological activity" @default.
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- W2657486574 doi "https://doi.org/10.1002/chir.22719" @default.
- W2657486574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28649696" @default.
- W2657486574 hasPublicationYear "2017" @default.