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• W2657974551 abstract "Transcription factor C/EBPα is a master regulator of myelopoiesis and its inactivation is associated with acute myeloid leukemia. Deregulation of C/EBPα by microRNAs during granulopoiesis or acute myeloid leukemia development has not been studied. Here we show that oncogenic miR-182 is a strong regulator of C/EBPα. Moreover, we identify a regulatory loop between C/EBPα and miR-182. While C/EBPα blocks miR-182 expression by direct promoter binding during myeloid differentiation, enforced expression of miR-182 reduces C/EBPα protein level and impairs granulopoiesis in vitro and in vivo. In addition, miR-182 expression is highly elevated particularly in acute myeloid leukemia patients with C-terminal CEBPA mutations, thereby depicting a mechanism by which C/EBPα blocks miR-182 expression. Furthermore, we present miR-182 expression as a prognostic marker in cytogenetically high-risk acute myeloid leukemia patients. Our data demonstrate the importance of a controlled balance between C/EBPα and miR-182 for the maintenance of healthy granulopoiesis. C/EBPα is a critical transcription factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (AML). Here the authors show a negative feedback loop between C/EBPα and miR-182 and identify this miRNA as a marker of high-risk AML." @default.
• W2657974551 created "2017-06-30" @default.
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• W2657974551 date "2017-06-29" @default.
• W2657974551 modified "2023-10-18" @default.
• W2657974551 title "Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation" @default.
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• W2657974551 doi "https://doi.org/10.1038/s41467-017-00032-6" @default.
• W2657974551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5491528" @default.
• W2657974551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28663557" @default.
• W2657974551 hasPublicationYear "2017" @default.
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