Matches in SemOpenAlex for { <https://semopenalex.org/work/W265804102> ?p ?o ?g. }
- W265804102 endingPage "127" @default.
- W265804102 startingPage "107" @default.
- W265804102 abstract "Marfan Syndrome (MFS) and Loeys-Dietz Syndrome (LDS) represent heritable connective tissue disorders that cosegregate with a similar pattern of cardiovascular defects (thoracic aortic aneurysm, mitral valve prolapse/regurgitation, and aortic root dilatation with regurgitation). This pattern of cardiovascular defects appears to be expressed along a spectrum of severity in many heritable connective tissue disorders and raises suspicion of a relationship between the normal development of connective tissues and the cardiovascular system. Given the evidence of increased transforming growth factor-beta (TGF-β) signaling in MFS and LDS, this signaling pathway may represent the common link in this relationship. To further explore this hypothetical link, this chapter will review the TGF-β signaling pathway, heritable connective tissue syndromes related to TGF-β receptor (TGFBR) mutations, and discuss the pathogenic contribution of TGF-β to these syndromes with a primary focus on the cardiovascular system." @default.
- W265804102 created "2016-06-24" @default.
- W265804102 creator A5030359399 @default.
- W265804102 creator A5036986605 @default.
- W265804102 creator A5061655266 @default.
- W265804102 date "2013-12-14" @default.
- W265804102 modified "2023-10-12" @default.
- W265804102 title "Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-Beta Signaling" @default.
- W265804102 cites W1494055834 @default.
- W265804102 cites W1505978562 @default.
- W265804102 cites W1553444759 @default.
- W265804102 cites W1561940208 @default.
- W265804102 cites W1575754639 @default.
- W265804102 cites W1589859980 @default.
- W265804102 cites W1636022999 @default.
- W265804102 cites W1840163537 @default.
- W265804102 cites W1913173932 @default.
- W265804102 cites W1966170741 @default.
- W265804102 cites W1967014478 @default.
- W265804102 cites W1967981485 @default.
- W265804102 cites W1968509366 @default.
- W265804102 cites W1969989929 @default.
- W265804102 cites W1972505984 @default.
- W265804102 cites W1974955986 @default.
- W265804102 cites W1975417642 @default.
- W265804102 cites W1978053309 @default.
- W265804102 cites W1978999523 @default.
- W265804102 cites W1980246797 @default.
- W265804102 cites W1980569478 @default.
- W265804102 cites W1982066003 @default.
- W265804102 cites W1983313606 @default.
- W265804102 cites W1986567780 @default.
- W265804102 cites W1991963554 @default.
- W265804102 cites W1993629981 @default.
- W265804102 cites W1997216820 @default.
- W265804102 cites W2004087842 @default.
- W265804102 cites W2004184538 @default.
- W265804102 cites W2005259727 @default.
- W265804102 cites W2007431373 @default.
- W265804102 cites W2008869198 @default.
- W265804102 cites W2009396278 @default.
- W265804102 cites W2010410229 @default.
- W265804102 cites W2011196754 @default.
- W265804102 cites W2011610612 @default.
- W265804102 cites W2012409690 @default.
- W265804102 cites W2012617974 @default.
- W265804102 cites W2013100626 @default.
- W265804102 cites W2013701595 @default.
- W265804102 cites W2017201371 @default.
- W265804102 cites W2017345365 @default.
- W265804102 cites W2017410696 @default.
- W265804102 cites W2018790447 @default.
- W265804102 cites W2019334654 @default.
- W265804102 cites W2019451592 @default.
- W265804102 cites W2020639229 @default.
- W265804102 cites W2021263701 @default.
- W265804102 cites W2023431960 @default.
- W265804102 cites W2028919524 @default.
- W265804102 cites W2029399343 @default.
- W265804102 cites W2029930661 @default.
- W265804102 cites W2031667124 @default.
- W265804102 cites W2032142079 @default.
- W265804102 cites W2036286400 @default.
- W265804102 cites W2037787006 @default.
- W265804102 cites W2038587058 @default.
- W265804102 cites W2041175002 @default.
- W265804102 cites W2043542059 @default.
- W265804102 cites W2044887819 @default.
- W265804102 cites W2047187176 @default.
- W265804102 cites W2051889170 @default.
- W265804102 cites W2054351373 @default.
- W265804102 cites W2058382167 @default.
- W265804102 cites W2058734183 @default.
- W265804102 cites W2060321450 @default.
- W265804102 cites W2060372234 @default.
- W265804102 cites W2060984299 @default.
- W265804102 cites W2061471122 @default.
- W265804102 cites W2061690134 @default.
- W265804102 cites W2064297038 @default.
- W265804102 cites W2065349942 @default.
- W265804102 cites W2066270582 @default.
- W265804102 cites W2069865494 @default.
- W265804102 cites W2070078805 @default.
- W265804102 cites W2071187539 @default.
- W265804102 cites W2073524710 @default.
- W265804102 cites W2075998623 @default.
- W265804102 cites W2076439289 @default.
- W265804102 cites W2076452337 @default.
- W265804102 cites W2080299984 @default.
- W265804102 cites W2081791687 @default.
- W265804102 cites W2082408176 @default.
- W265804102 cites W2083713591 @default.
- W265804102 cites W2088192062 @default.
- W265804102 cites W2094876614 @default.
- W265804102 cites W2096384326 @default.
- W265804102 cites W2097470178 @default.
- W265804102 cites W2100398824 @default.
- W265804102 cites W2100523257 @default.