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• W2658628051 endingPage "e0178916" @default.
• W2658628051 startingPage "e0178916" @default.
• W2658628051 abstract "To our knowledge, the effects of Spirulina platensis water extract (SP) on hearing function have not yet been reported. This study investigated the effects of SP on the function and redox status of the auditory system. Auditory brainstem responses and redox status were compared between two groups of 3-month-old senescence-accelerated prone-8 (SAMP8) mice: the control group was fed a normal diet, and the experimental group was fed a normal diet with oral supplementation of SP for 6 weeks. Compared with the control group, the experimental group had significantly lower hearing thresholds according to auditory brainstem responses measured using click sounds and 8-kHz tone burst sound stimulation at the end of this study. The experimental group had a shorter I-III interval of auditory brainstem responses with 16-kHz tone burst stimulation than the control group that was of borderline significance. Additionally, the experimental group had significantly higher mRNA expression of the superoxide dismutase and catalase genes in the cochlea and brainstem and significantly higher mRNA expression of the glutathione peroxidase gene in the cochlea. Further, the experimental group had significantly lower malondialdehyde levels in the cochlea and brainstem than the control group. However, tumor necrosis factor-α mRNA expression was not significantly different between the control and experimental groups. SP could decrease hearing degeneration in senescence-accelerated prone-8 mice possibly by increasing superoxide dismutase, catalase, and glutathione peroxidase gene expression and decreasing damage from oxidative stress in the cochlea and brainstem." @default.
• W2658628051 created "2017-06-30" @default.
• W2658628051 creator A5028530239 @default.
• W2658628051 creator A5086546681 @default.
• W2658628051 date "2017-06-21" @default.
• W2658628051 modified "2023-09-25" @default.
• W2658628051 title "Effects of Spirulina on the functions and redox status of auditory system in senescence-accelerated prone-8 mice" @default.
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• W2658628051 doi "https://doi.org/10.1371/journal.pone.0178916" @default.
• W2658628051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5764409" @default.
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• W2658628051 hasPublicationYear "2017" @default.
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