Matches in SemOpenAlex for { <https://semopenalex.org/work/W2660058842> ?p ?o ?g. }
- W2660058842 endingPage "1414" @default.
- W2660058842 startingPage "1400" @default.
- W2660058842 abstract "The unique spectral signatures and biologically inert compositions of surface-enhanced resonance Raman scattering (SERRS) nanoparticles make them promising contrast agents for in vivo cancer imaging. Our SERRS nanoparticles consist of a 60-nm gold nanoparticle core that is encapsulated in a 15-nm-thick silica shell wherein the resonant Raman reporter is embedded. Subtle aspects of their preparation can shift their limit of detection by orders of magnitude. In this protocol, we present the optimized, step-by-step procedure for generating reproducible SERRS nanoparticles with femtomolar (10-15 M) limits of detection. We provide ways of characterizing the optical properties of SERRS nanoparticles using UV/VIS and Raman spectroscopy, and their physicochemical properties using transmission electron microscopy and nanoparticle tracking analysis. We introduce several applications of these nanoprobes for biomedical research, with a focus on intraoperative cancer imaging via Raman imaging. A detailed account is provided for successful i.v. administration of SERRS nanoparticles such that delineation of cancerous lesions can be achieved in vivo and ex vivo on resected tissues without the need for specific biomarker targeting. This straightforward, yet comprehensive, protocol-from initial de novo gold nanoparticle synthesis to SERRS nanoparticle contrast-enhanced preclinical Raman imaging in animal models-takes ∼96 h." @default.
- W2660058842 created "2017-06-30" @default.
- W2660058842 creator A5022596326 @default.
- W2660058842 creator A5028896005 @default.
- W2660058842 creator A5035464945 @default.
- W2660058842 creator A5089610336 @default.
- W2660058842 date "2017-06-22" @default.
- W2660058842 modified "2023-09-30" @default.
- W2660058842 title "Cancer imaging using surface-enhanced resonance Raman scattering nanoparticles" @default.
- W2660058842 cites W1543914022 @default.
- W2660058842 cites W1989137548 @default.
- W2660058842 cites W2002516695 @default.
- W2660058842 cites W2005535113 @default.
- W2660058842 cites W2006370393 @default.
- W2660058842 cites W2013412470 @default.
- W2660058842 cites W2017371967 @default.
- W2660058842 cites W2021448456 @default.
- W2660058842 cites W2022524943 @default.
- W2660058842 cites W2023330178 @default.
- W2660058842 cites W2026836316 @default.
- W2660058842 cites W2032199994 @default.
- W2660058842 cites W2038750423 @default.
- W2660058842 cites W2043798557 @default.
- W2660058842 cites W2075646173 @default.
- W2660058842 cites W2076440513 @default.
- W2660058842 cites W2080202676 @default.
- W2660058842 cites W2085914647 @default.
- W2660058842 cites W2089124524 @default.
- W2660058842 cites W2089557457 @default.
- W2660058842 cites W2089906568 @default.
- W2660058842 cites W2090367417 @default.
- W2660058842 cites W2096138335 @default.
- W2660058842 cites W2099459454 @default.
- W2660058842 cites W2101282262 @default.
- W2660058842 cites W2106635129 @default.
- W2660058842 cites W2106739895 @default.
- W2660058842 cites W2107910518 @default.
- W2660058842 cites W2115029038 @default.
- W2660058842 cites W2115318086 @default.
- W2660058842 cites W2121686566 @default.
- W2660058842 cites W2122347920 @default.
- W2660058842 cites W2123852381 @default.
- W2660058842 cites W2128655898 @default.
- W2660058842 cites W2146542638 @default.
- W2660058842 cites W2150078595 @default.
- W2660058842 cites W2160700316 @default.
- W2660058842 cites W2165712367 @default.
- W2660058842 cites W2226340528 @default.
- W2660058842 cites W2289547149 @default.
- W2660058842 cites W2295097024 @default.
- W2660058842 cites W2306142233 @default.
- W2660058842 cites W2317653259 @default.
- W2660058842 cites W2318527211 @default.
- W2660058842 cites W2320908349 @default.
- W2660058842 cites W2339952160 @default.
- W2660058842 cites W2406768607 @default.
- W2660058842 cites W2498278049 @default.
- W2660058842 cites W2604694675 @default.
- W2660058842 cites W4234368842 @default.
- W2660058842 cites W4249497251 @default.
- W2660058842 doi "https://doi.org/10.1038/nprot.2017.031" @default.
- W2660058842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5694346" @default.
- W2660058842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28686581" @default.
- W2660058842 hasPublicationYear "2017" @default.
- W2660058842 type Work @default.
- W2660058842 sameAs 2660058842 @default.
- W2660058842 citedByCount "108" @default.
- W2660058842 countsByYear W26600588422017 @default.
- W2660058842 countsByYear W26600588422018 @default.
- W2660058842 countsByYear W26600588422019 @default.
- W2660058842 countsByYear W26600588422020 @default.
- W2660058842 countsByYear W26600588422021 @default.
- W2660058842 countsByYear W26600588422022 @default.
- W2660058842 countsByYear W26600588422023 @default.
- W2660058842 crossrefType "journal-article" @default.
- W2660058842 hasAuthorship W2660058842A5022596326 @default.
- W2660058842 hasAuthorship W2660058842A5028896005 @default.
- W2660058842 hasAuthorship W2660058842A5035464945 @default.
- W2660058842 hasAuthorship W2660058842A5089610336 @default.
- W2660058842 hasBestOaLocation W26600588422 @default.
- W2660058842 hasConcept C104819515 @default.
- W2660058842 hasConcept C120665830 @default.
- W2660058842 hasConcept C121332964 @default.
- W2660058842 hasConcept C136339569 @default.
- W2660058842 hasConcept C15083742 @default.
- W2660058842 hasConcept C150903083 @default.
- W2660058842 hasConcept C155672457 @default.
- W2660058842 hasConcept C169573571 @default.
- W2660058842 hasConcept C171250308 @default.
- W2660058842 hasConcept C185592680 @default.
- W2660058842 hasConcept C192562407 @default.
- W2660058842 hasConcept C207001950 @default.
- W2660058842 hasConcept C2777790068 @default.
- W2660058842 hasConcept C29331040 @default.
- W2660058842 hasConcept C40003534 @default.
- W2660058842 hasConcept C86803240 @default.
- W2660058842 hasConceptScore W2660058842C104819515 @default.
- W2660058842 hasConceptScore W2660058842C120665830 @default.