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• W2660075844 abstract "Stilbenes have long been in focus of scientific interest due to their diverse biological activities. In order to explore molecules possessing superior biological profile, a series of novel stilbene derivatives (9-19) containing pyridine moiety have been synthesized and evaluated for their antimicrobial, antioxidant and anticancer potential. Compounds 11, 16, 17, 18 and 19 exhibited activity against P. aeruginosa (MIC = 50 µg/mL) on par with ampicillin. With regards to fungicidal activity against C. albicans, compounds 11, 13 and 14 showed comparable activity with nystatin (MIC = 3.1 µg/mL). Further, compounds 17 and 19 possess good antioxidant properties. In addition, compound 19 exhibited strong anticancer activity with IC50 values of 12.38 ± 6.83 µM and 14.52 ± 2.21 µM against two cancer cell lines PC-3 and MCF-7 respectively. Thus, compound 3-Bromo-3', 4'-dihydroxy stilbene-2-nitrogen (19) may be considered a lead molecule possessing diverse biological activity for further development." @default.
• W2660075844 created "2017-06-30" @default.
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• W2660075844 date "2015-02-01" @default.
• W2660075844 modified "2023-09-27" @default.
• W2660075844 title "Stilbene heterocycles: Synthesis, antimicrobial, antioxidant and anticancer activities" @default.
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