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- W266156907 abstract "Characteristically, MM cells harbour to the BM compartment whereas extensive extramedullary growth is mainly observed in the terminal phase of the desease. The principal goal of this work was to study the interaction between MM cells and bone cells, i.e. osteoblasts and osteoclasts. Earlier our group showed that most MM cells produce HGF (198). Both osteoblasts and osteoclasts express the HFG receptor c-met (182), and effects of HGF on activity, survival, adhesion, migration, or the production of other factors from these cell types may be of importance. The second aim of this study was to identify other MM cell-derived factors with effects on bone cells or the ECM in bone. Finally, MM cells do not only influence the BM but the MM cells themselves are highly affected by this environment, for instance by stromal IL-6 production. Therefore, we were interested in local factors produced by the osteoblasts or osteoclasts that could affect MM cells, either in a stimulatory manner in analogy to paracrine IL-6 production, or in an inhibitory manner." @default.
- W266156907 created "2016-06-24" @default.
- W266156907 creator A5028791599 @default.
- W266156907 date "2001-01-01" @default.
- W266156907 modified "2023-10-17" @default.
- W266156907 title "Multiple myeloma : Interactions between malignant plasma cells and the bone microenvironment" @default.
- W266156907 hasPublicationYear "2001" @default.
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