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• W26616567 abstract "A series of experiments were initiated to study the influence of calcium on morphine action. The analgetic effect of morphine in non-tolerant and tolerant mice was found to be antagonized by intraventricular calcium and enhanced by the cation chelator EGTA. Elevation of brain bioamines by monoamine oxidase inhibition (pargyline) or reducing brain catecholamine by chemical sympathectomy (6-hydroxydopamine) failed to alter the calcium effect. Enhancing calcium influx with the ionophore X537A also decreased morphine analgesia while inhibition of calcium binding to and movement across cell membrane by lanthanum greatly augmented morphine analgesia. Interestingly, lanthanum per se produced analgesia in both mice and rats and the action was inhibited by the narcotic antagonist, naloxone. Moreover, the analgetic sensitive sites in the CNS to lanthanum and morphine were both found to be in the periventricular and periaqueductal gray areas. Cross tolerance between lanthanum and morphine was noted and lanthanum attenuated the withdrawal syndrome in morphine-dependent mice. The development of tolerance to morphine was accompanied by an increased level of calcium in synaptosomes and a decrease in high affinity calcium binding to the synaptosomal plasma membrane fraction but not to the other membrane fractions studied. The effects suggest that chronic morphine treatment decreases the availability of calcium binding sites on the inner surface of the synaptosomal membrane." @default.
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• W26616567 date "1978-01-01" @default.
• W26616567 modified "2023-10-16" @default.
• W26616567 title "EFFECT OF CALCIUM AND LANTHANUM IN MORPHINE ANALGESIA AND TOLERANCE" @default.
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• W26616567 doi "https://doi.org/10.1016/b978-1-4832-8322-7.50174-6" @default.
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