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- W26673457 abstract "The existence of a membrane-bound semicarbazide-sensitive amine oxidase (SSAO) is well established in various mammalian tissues, especially within vascular smooth muscle, but its importance and the possible consequences of its metabolism of certain physiological and xenobiotic amines in vivo are under investigation. In this respect, there are major species-related differences in substrate specificity determined in vitro, not only towards the synthetic amine benzylamine, but also towards some other aromatic amines that are possible endogenous substrates. Inhibition of SSAO can potentiate the pharmacological activity of some amines in isolated tissue preparations from some species. Evidence has accumulated that SSAO may also be involved in metabolizing endogenous aliphatic amines, such as methylamine and aminoacetone, focussing attention on the fact that aldehyde products are potentially cytotoxic agents. SSAO has been implicated in the experimental models of cardiovascular toxicity, involving a conversion of the industrial aliphatic amine, allylamine, to acrolein. Metabolism by SSAO may reduce the physiological/pharmacological effects of some amines, but the resulting metabolites may also have important actions." @default.
- W26673457 created "2016-06-24" @default.
- W26673457 creator A5084182591 @default.
- W26673457 date "1995-01-01" @default.
- W26673457 modified "2023-10-10" @default.
- W26673457 title "Chapter 30 Substrate-specificity of mammalian tissue-bound semicarbazide-sensitive amine oxidase" @default.
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- W26673457 doi "https://doi.org/10.1016/s0079-6123(08)61226-1" @default.
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