FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2667727020> ?p ?o ?g. }

• W2667727020 endingPage "2106" @default.
• W2667727020 startingPage "2097" @default.
• W2667727020 abstract "The use of nitric oxide (NO) as a signal for biofilm dispersal has been shown to increase the susceptibility of many biofilms to antibiotics, promoting their eradication. The delivery of NO to biofilms can be achieved by using NO donors with different kinetics and properties of NO release that can influence their efficacy as biofilm control agents. In this study, the kinetics of three furoxan derivatives were evaluated. The effects of these NO donors, which have an advantageous pharmacological profile of slower onset with an extended duration of action, on Pseudomonas aeruginosa growth, biofilm development, and dispersal were also characterized. Compound LL4254, which showed a fast rate of NO release, induced biofilm dispersal at approximately 200 μM. While LL4212 and LL4216 have a slower rate of NO release, both compounds could induce biofilm dispersal, under the same treatment conditions, when used at higher concentrations. In addition, LL4212 and LL4216 were found to promote P. aeruginosa growth in iron-limited minimal medium, leading to a faster rate of biofilm formation and glucose utilization, and ultimately resulted in early dispersal of biofilm cells through carbon starvation. High concentrations of LL4216 also repressed production of the siderophore pyoverdine by more than 50-fold, via both NOx-dependent and NOx-independent mechanisms. The effects on growth and pyoverdine levels exerted by the furoxans appeared to be mediated by NO-independent mechanisms, suggesting functional activities of furoxans in addition to their release of NO and nitrite. Overall, this study reveals that secondary effects of furoxans are important considerations for their use as NO-releasing dispersal agents and that these compounds could be potentially redesigned as pyoverdine inhibitors." @default.
• W2667727020 created "2017-06-30" @default.
• W2667727020 creator A5009764916 @default.
• W2667727020 creator A5021721399 @default.
• W2667727020 creator A5026659281 @default.
• W2667727020 creator A5046219151 @default.
• W2667727020 creator A5047107350 @default.
• W2667727020 creator A5053126836 @default.
• W2667727020 creator A5085797426 @default.
• W2667727020 date "2017-06-29" @default.
• W2667727020 modified "2023-10-16" @default.
• W2667727020 title "Furoxan Nitric Oxide Donors Disperse <i>Pseudomonas aeruginosa</i> Biofilms, Accelerate Growth, and Repress Pyoverdine Production" @default.
• W2667727020 cites W1479760463 @default.
• W2667727020 cites W1635778238 @default.
• W2667727020 cites W1945366320 @default.
• W2667727020 cites W1963885628 @default.
• W2667727020 cites W1968369755 @default.
• W2667727020 cites W1980458823 @default.
• W2667727020 cites W1981946882 @default.
• W2667727020 cites W1996442931 @default.
• W2667727020 cites W1999208772 @default.
• W2667727020 cites W2014250987 @default.
• W2667727020 cites W2026294448 @default.
• W2667727020 cites W2026856098 @default.
• W2667727020 cites W2029217496 @default.
• W2667727020 cites W2036650492 @default.
• W2667727020 cites W2037966968 @default.
• W2667727020 cites W2045825103 @default.
• W2667727020 cites W2049005741 @default.
• W2667727020 cites W2057460683 @default.
• W2667727020 cites W2092427534 @default.
• W2667727020 cites W2095586932 @default.
• W2667727020 cites W2095670455 @default.
• W2667727020 cites W2097314730 @default.
• W2667727020 cites W2099143902 @default.
• W2667727020 cites W2106016893 @default.
• W2667727020 cites W2123071440 @default.
• W2667727020 cites W2125603952 @default.
• W2667727020 cites W2126601632 @default.
• W2667727020 cites W2127535305 @default.
• W2667727020 cites W2128699796 @default.
• W2667727020 cites W2134511029 @default.
• W2667727020 cites W2146104034 @default.
• W2667727020 cites W2149908911 @default.
• W2667727020 cites W2152869680 @default.
• W2667727020 cites W2154276487 @default.
• W2667727020 cites W2157192184 @default.
• W2667727020 cites W2318805825 @default.
• W2667727020 cites W2401050920 @default.
• W2667727020 doi "https://doi.org/10.1021/acschembio.7b00256" @default.
• W2667727020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28628310" @default.
• W2667727020 hasPublicationYear "2017" @default.
• W2667727020 type Work @default.
• W2667727020 sameAs 2667727020 @default.
• W2667727020 citedByCount "18" @default.
• W2667727020 countsByYear W26677270202018 @default.
• W2667727020 countsByYear W26677270202019 @default.
• W2667727020 countsByYear W26677270202020 @default.
• W2667727020 countsByYear W26677270202021 @default.
• W2667727020 countsByYear W26677270202022 @default.
• W2667727020 countsByYear W26677270202023 @default.
• W2667727020 crossrefType "journal-article" @default.
• W2667727020 hasAuthorship W2667727020A5009764916 @default.
• W2667727020 hasAuthorship W2667727020A5021721399 @default.
• W2667727020 hasAuthorship W2667727020A5026659281 @default.
• W2667727020 hasAuthorship W2667727020A5046219151 @default.
• W2667727020 hasAuthorship W2667727020A5047107350 @default.
• W2667727020 hasAuthorship W2667727020A5053126836 @default.
• W2667727020 hasAuthorship W2667727020A5085797426 @default.
• W2667727020 hasConcept C104317684 @default.
• W2667727020 hasConcept C105923489 @default.
• W2667727020 hasConcept C108319773 @default.
• W2667727020 hasConcept C121332964 @default.
• W2667727020 hasConcept C12554922 @default.
• W2667727020 hasConcept C144024400 @default.
• W2667727020 hasConcept C148898269 @default.
• W2667727020 hasConcept C149923435 @default.
• W2667727020 hasConcept C178790620 @default.
• W2667727020 hasConcept C185592680 @default.
• W2667727020 hasConcept C203032635 @default.
• W2667727020 hasConcept C2776179834 @default.
• W2667727020 hasConcept C2776384668 @default.
• W2667727020 hasConcept C2776948483 @default.
• W2667727020 hasConcept C2777593127 @default.
• W2667727020 hasConcept C2777637488 @default.
• W2667727020 hasConcept C2908647359 @default.
• W2667727020 hasConcept C47559259 @default.
• W2667727020 hasConcept C519581460 @default.
• W2667727020 hasConcept C523546767 @default.
• W2667727020 hasConcept C54355233 @default.
• W2667727020 hasConcept C55493867 @default.
• W2667727020 hasConcept C58123911 @default.
• W2667727020 hasConcept C62520636 @default.
• W2667727020 hasConcept C86803240 @default.
• W2667727020 hasConcept C89423630 @default.
• W2667727020 hasConceptScore W2667727020C104317684 @default.
• W2667727020 hasConceptScore W2667727020C105923489 @default.
• W2667727020 hasConceptScore W2667727020C108319773 @default.

• next