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- W2667760530 abstract "Colorectal cancer (CRC) is one of the most common tumors world wild. High cholesterol diet is considered a risk for CRC development. Cholesterol oxidation products, namely oxysterols, have been shown to have a role in human degenerative diseases, mainly for their ability to favor inflammatory reactions. Therefore, they could be involved in inducing intestinal inflammation, a process strongly associated to colorectal carcinogenesis. Dietary oxysterols could derange intestinal epithelial barrier by inducing the activation of metalloproteinases (MMPs) as well as the decrease of tight junctions (TJs), which are essential in mucosa barrier maintenance. Enterocyte-like CaCo-2 cells were treated with a mixture of oxysterols representative of a hyper-cholesterol diet. The time course study of MMPs activity (MMP-9 and MMP-2) showed their significant increase, reaching the maximum at 72 hours treatment. Moreover, the dietary oxysterols decreased the TJ production, in particular of junctional adhesion molecule (JAM), zonula occludens (ZO) and occludin. These two events appeared to be associated. In fact, cell pretreatment with specific MMPs inhibitors restored TJ levels. Therefore, dietary oxysterols could be actually implicated in tumor progression towards a more aggressive phenotype by inducing extracellular matrix destabilization and intestinal barrier disruption." @default.
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- W2667760530 date "2017-07-01" @default.
- W2667760530 modified "2023-09-27" @default.
- W2667760530 title "Oxysterols are involved in colorectal carcinogenesis by damaging intestinal layer" @default.
- W2667760530 doi "https://doi.org/10.1016/j.freeradbiomed.2017.04.340" @default.
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