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- W2668394371 abstract "This chapter provides definitions for dilution, reconstitution, and diffusion, and reviews the clinical evidence pertaining to safety and efficacy when these parameters are varied. It also focuses primarily on aesthetic use of botulinum toxin A. Modification of the botulinum toxin reconstitution regimen has been definitively shown to reduce pain and discomfort on injection. Two distinct approaches have been used to study diffusion and migration of toxin from the point of injection. The first is a clinical assessment of the locus of reduction of dynamic creases of the upper face, and the correspondence of this phenomenon with the likely spread of the toxin; the second is a clinical assessment of the radius of an induced hypohidrotic halo around the point of injection. The chapter recommends reconstitution with bacteriostatic saline containing benzyl alcohol given the preponderance of evidence of improved tolerability and possible improved safety profile, particularly with multiple patients using single-use vials." @default.
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- W2668394371 date "2017-06-23" @default.
- W2668394371 modified "2023-09-27" @default.
- W2668394371 title "Reconstitution, Dilution, Diffusion, and Migration of Botulinum Toxin" @default.
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- W2668394371 doi "https://doi.org/10.1002/9781118661833.ch8" @default.
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