FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2669810548> ?p ?o ?g. }

• W2669810548 endingPage "78" @default.
• W2669810548 startingPage "65" @default.
• W2669810548 abstract "Breast cancer represents a major health challenge. The majority of breast cancer deaths are due to cancer progression/recurrence for which no efficient therapies exist. Aggressive breast cancers are characterized by loss of cellular differentiation. Defining molecular mechanisms/targets contributing to cancer aggressiveness is needed to guide the design of new screening and targeted treatments. Here, we describe a novel tumor promoting function for the Cleavage and Polyadenylation Factor-6 (CPSF6). Importantly, aggressive breast cancer cells of luminal B, HER2-overexpressing and triple negative subtypes show dependency on CPSF6 for viability and tumorigenic capacity. Mechanistically, we found CPSF6 to interact with components of the A-to-I RNA editing machinery, paraspeckles and ADAR1 enzyme, and to be required for their physical integrity. Clinically, we found CPSF6 and all core paraspeckles proteins to be overexpressed in human breast cancer cases and their expression to correlate with poor patient outcomes. Finally, we found prolactin, a key mammary differentiation factor, to suppress CPSF6/RNA editing activity. Together, this study revealed CPSF6 as a molecular target with clinical relevance for prognosis and therapy in breast cancer." @default.
• W2669810548 created "2017-06-30" @default.
• W2669810548 creator A5009553059 @default.
• W2669810548 creator A5016667677 @default.
• W2669810548 creator A5025132882 @default.
• W2669810548 creator A5091794314 @default.
• W2669810548 date "2017-07-01" @default.
• W2669810548 modified "2023-10-16" @default.
• W2669810548 title "CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target" @default.
• W2669810548 cites W1128908913 @default.
• W2669810548 cites W1780552285 @default.
• W2669810548 cites W1786164458 @default.
• W2669810548 cites W1977918192 @default.
• W2669810548 cites W1986724703 @default.
• W2669810548 cites W2020652334 @default.
• W2669810548 cites W2022046147 @default.
• W2669810548 cites W2026168910 @default.
• W2669810548 cites W2027403969 @default.
• W2669810548 cites W2044702943 @default.
• W2669810548 cites W2054043881 @default.
• W2669810548 cites W2074981026 @default.
• W2669810548 cites W2077813812 @default.
• W2669810548 cites W2081571678 @default.
• W2669810548 cites W2085934079 @default.
• W2669810548 cites W2087351768 @default.
• W2669810548 cites W2096009089 @default.
• W2669810548 cites W2097255042 @default.
• W2669810548 cites W2104504930 @default.
• W2669810548 cites W2106774938 @default.
• W2669810548 cites W2122289183 @default.
• W2669810548 cites W2128719162 @default.
• W2669810548 cites W2131994307 @default.
• W2669810548 cites W2137204308 @default.
• W2669810548 cites W2143584784 @default.
• W2669810548 cites W2153450669 @default.
• W2669810548 cites W2156538352 @default.
• W2669810548 cites W2160858975 @default.
• W2669810548 cites W2161696113 @default.
• W2669810548 cites W2164511212 @default.
• W2669810548 cites W2166311434 @default.
• W2669810548 cites W2167907059 @default.
• W2669810548 cites W2171015116 @default.
• W2669810548 cites W2207283323 @default.
• W2669810548 cites W2259802687 @default.
• W2669810548 cites W2301343927 @default.
• W2669810548 cites W2325314951 @default.
• W2669810548 cites W2484544705 @default.
• W2669810548 doi "https://doi.org/10.1016/j.ebiom.2017.06.023" @default.
• W2669810548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5514498" @default.
• W2669810548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28673861" @default.
• W2669810548 hasPublicationYear "2017" @default.
• W2669810548 type Work @default.
• W2669810548 sameAs 2669810548 @default.
• W2669810548 citedByCount "35" @default.
• W2669810548 countsByYear W26698105482018 @default.
• W2669810548 countsByYear W26698105482019 @default.
• W2669810548 countsByYear W26698105482020 @default.
• W2669810548 countsByYear W26698105482021 @default.
• W2669810548 countsByYear W26698105482022 @default.
• W2669810548 countsByYear W26698105482023 @default.
• W2669810548 crossrefType "journal-article" @default.
• W2669810548 hasAuthorship W2669810548A5009553059 @default.
• W2669810548 hasAuthorship W2669810548A5016667677 @default.
• W2669810548 hasAuthorship W2669810548A5025132882 @default.
• W2669810548 hasAuthorship W2669810548A5091794314 @default.
• W2669810548 hasBestOaLocation W26698105481 @default.
• W2669810548 hasConcept C104317684 @default.
• W2669810548 hasConcept C121608353 @default.
• W2669810548 hasConcept C142575336 @default.
• W2669810548 hasConcept C502942594 @default.
• W2669810548 hasConcept C530470458 @default.
• W2669810548 hasConcept C54355233 @default.
• W2669810548 hasConcept C60644358 @default.
• W2669810548 hasConcept C62531158 @default.
• W2669810548 hasConcept C67705224 @default.
• W2669810548 hasConcept C71924100 @default.
• W2669810548 hasConcept C86803240 @default.
• W2669810548 hasConceptScore W2669810548C104317684 @default.
• W2669810548 hasConceptScore W2669810548C121608353 @default.
• W2669810548 hasConceptScore W2669810548C142575336 @default.
• W2669810548 hasConceptScore W2669810548C502942594 @default.
• W2669810548 hasConceptScore W2669810548C530470458 @default.
• W2669810548 hasConceptScore W2669810548C54355233 @default.
• W2669810548 hasConceptScore W2669810548C60644358 @default.
• W2669810548 hasConceptScore W2669810548C62531158 @default.
• W2669810548 hasConceptScore W2669810548C67705224 @default.
• W2669810548 hasConceptScore W2669810548C71924100 @default.
• W2669810548 hasConceptScore W2669810548C86803240 @default.
• W2669810548 hasFunder F4320334506 @default.
• W2669810548 hasLocation W26698105481 @default.
• W2669810548 hasLocation W26698105482 @default.
• W2669810548 hasLocation W26698105483 @default.
• W2669810548 hasLocation W26698105484 @default.
• W2669810548 hasOpenAccess W2669810548 @default.
• W2669810548 hasPrimaryLocation W26698105481 @default.
• W2669810548 hasRelatedWork W1605090496 @default.
• W2669810548 hasRelatedWork W1977380477 @default.
• W2669810548 hasRelatedWork W1978629561 @default.

• next