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- W2670086117 abstract "The medial prefrontal cortex (mPFC) is necessary for the formation of contextualrepresentations and memory expression following fear conditioning. Recent studieshave shown learning-dependent changes in the intrinsic excitability of mPFC neurons.It is not clear, however, whether these changes are region-wide or neuron-typespecific. The specific connectivity and intrinsic properties of different neuronal typescould cause certain neuronal populations to be preferentially involved in informationprocessing in a learning paradigm. In this project, we investigated this hypothesis bystudying the plasticity of intrinsic excitability in the prelimbic (PL) part of the mPFCin two defined neuronal groups: those projecting to the ipsilateral amygdala and thoseprojecting to the contralateral mPFC. We used contextual fear conditioning togetherwith retrograde tracing and whole-cell electrophysiological recordings of labelledpyramidal neurons in adult 2-3 month old male C56BL/6J mice. We show thatneurons projecting to the amygdala display learning-dependent changes in neuronalexcitability following contextual fear conditioning. In contrast, the excitability ofneurons projecting to the contralateral mPFC does not differ between trained andcontrol animals. Together, these results indicate that learning-induced changes inintrinsic excitability are not generalised across all PL neurons but instead are definedby the neurons’ long-range projection targets." @default.
- W2670086117 created "2017-06-30" @default.
- W2670086117 creator A5024707900 @default.
- W2670086117 date "2014-06-13" @default.
- W2670086117 modified "2023-09-25" @default.
- W2670086117 title "Long-range connectivity defines learning-induced intrinsic plasticity of prelimbic neurons" @default.
- W2670086117 hasPublicationYear "2014" @default.
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