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- W26710017 abstract "Abortion is considered a multifactorial problem, the most important causes involvedin its etiology are, environmental factors ( as exposure to toxic chemicals), genetic,anatomic, endocrine, immunological, thrombophilic and infectious diseases (such astoxoplasmosis, rubella). However, genetic factors are mainly attributed to abortions ofthe first trimester of pregnancy. Chromosomal abnormalities, MTHFR 677C>T, factorV Leiden 1691G>A and prothrombin 20210G>A mutations have been associatedwith obstetric problems, including recurrent miscarriage. The objective of thisresearch was to investigate associations between mutations in three genescommonly associated to thrombophilic events, chromosomal abnormalities and theoccurrence of recurrent miscarriage. As well evaluate possible interactions betweenthese mutations and chromosomal abnormalities. The sample was comprised of 151women with history of recurrent miscarriages, 94 partners and 100 control (womenwith no history of abortion). The investigation of the mutations was performed byPolymerase Chain Reaction (PCR)/ Restriction Fragment Length Polymorphism(RFLP). Chromosomal aberrations were investigated by karyotyping with G-banda.The frequency of chromosomal abnormalities was 7.3% in women with recurrentmiscarriage and 1% in controls (p = 0.022), and 2.1% in the partners. However, thefrequency of allele MTHR677C> T (23% versus 22.5%), FVL1691G> A (1.5% vs.1%) and PRT20210G> A (1.45% vs. 0%) was similar for cases and controls,respectively. In the investigated group was found association between recurrentmiscarriage and chromosomal abnormalities, but no association was found with thegenetic polymorphisms investigated." @default.
- W26710017 created "2016-06-24" @default.
- W26710017 creator A5042445924 @default.
- W26710017 date "2013-01-01" @default.
- W26710017 modified "2023-09-23" @default.
- W26710017 title "Alterações genéticas em casais com antecedentes de aborto recorrente no primeiro trimestre da gestação" @default.
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- W26710017 hasPublicationYear "2013" @default.
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