FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2671458188> ?p ?o ?g. }

• W2671458188 abstract "Abstract Autophagy is a protective and life-sustaining process in which cytoplasmic components are packaged into double-membrane vesicles and targeted to lysosomes for degradation. Accumulating evidence supports that autophagy is associated with several pathological conditions. However, research on the functional cross-links between autophagy and disease genes remains in its early stages. In this study, we constructed a disease-autophagy network (DAN) by integrating known disease genes, known autophagy genes and protein-protein interactions (PPI). Dissecting the topological properties of the DAN suggested that nodes that both autophagy and disease genes (inter-genes), are topologically important in the DAN structure. Next, a core network from the DAN was extracted to analyze the functional links between disease and autophagy genes. The genes in the core network were significantly enriched in multiple disease-related pathways, suggesting that autophagy genes may function in various disease processes. Of 17 disease classes, 11 significantly overlapped with autophagy genes, including cancer diseases, metabolic diseases and hematological diseases, a finding that is supported by the literatures. We also found that autophagy genes have a bridging role in the connections between pairs of disease classes. Altogether, our study provides a better understanding of the molecular mechanisms underlying human diseases and the autophagy process." @default.
• W2671458188 created "2017-06-30" @default.
• W2671458188 creator A5021360731 @default.
• W2671458188 creator A5023553088 @default.
• W2671458188 creator A5027797567 @default.
• W2671458188 creator A5042896525 @default.
• W2671458188 creator A5065279082 @default.
• W2671458188 date "2017-03-15" @default.
• W2671458188 modified "2023-09-27" @default.
• W2671458188 title "Network analysis reveals crosstalk between autophagy genes and disease genes" @default.
• W2671458188 cites W1523693806 @default.
• W2671458188 cites W1867054729 @default.
• W2671458188 cites W1968444524 @default.
• W2671458188 cites W1970674931 @default.
• W2671458188 cites W1979309473 @default.
• W2671458188 cites W1982475443 @default.
• W2671458188 cites W1997236289 @default.
• W2671458188 cites W2001623365 @default.
• W2671458188 cites W2007151442 @default.
• W2671458188 cites W2012255493 @default.
• W2671458188 cites W2013251910 @default.
• W2671458188 cites W2018045523 @default.
• W2671458188 cites W2045373134 @default.
• W2671458188 cites W2047341797 @default.
• W2671458188 cites W2048030072 @default.
• W2671458188 cites W2062533676 @default.
• W2671458188 cites W2063961010 @default.
• W2671458188 cites W2065031087 @default.
• W2671458188 cites W2068184295 @default.
• W2671458188 cites W2083045667 @default.
• W2671458188 cites W2083911670 @default.
• W2671458188 cites W2101181377 @default.
• W2671458188 cites W2109034822 @default.
• W2671458188 cites W2114944688 @default.
• W2671458188 cites W2130350123 @default.
• W2671458188 cites W2132871858 @default.
• W2671458188 cites W2134672568 @default.
• W2671458188 cites W2145879983 @default.
• W2671458188 cites W2154748862 @default.
• W2671458188 cites W2156245645 @default.
• W2671458188 cites W2158217645 @default.
• W2671458188 cites W2160403509 @default.
• W2671458188 cites W2160723825 @default.
• W2671458188 cites W2162151166 @default.
• W2671458188 cites W2201007235 @default.
• W2671458188 cites W2264982258 @default.
• W2671458188 cites W2290262760 @default.
• W2671458188 cites W2291350642 @default.
• W2671458188 cites W2292779485 @default.
• W2671458188 cites W2398113859 @default.
• W2671458188 cites W2399094071 @default.
• W2671458188 cites W2442837996 @default.
• W2671458188 cites W2461339380 @default.
• W2671458188 cites W2511042561 @default.
• W2671458188 cites W2519349636 @default.
• W2671458188 cites W2530936512 @default.
• W2671458188 cites W2534325220 @default.
• W2671458188 cites W2537630600 @default.
• W2671458188 doi "https://doi.org/10.1038/srep44391" @default.
• W2671458188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5353691" @default.
• W2671458188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28295050" @default.
• W2671458188 hasPublicationYear "2017" @default.
• W2671458188 type Work @default.
• W2671458188 sameAs 2671458188 @default.
• W2671458188 citedByCount "5" @default.
• W2671458188 countsByYear W26714581882017 @default.
• W2671458188 countsByYear W26714581882018 @default.
• W2671458188 countsByYear W26714581882020 @default.
• W2671458188 countsByYear W26714581882021 @default.
• W2671458188 crossrefType "journal-article" @default.
• W2671458188 hasAuthorship W2671458188A5021360731 @default.
• W2671458188 hasAuthorship W2671458188A5023553088 @default.
• W2671458188 hasAuthorship W2671458188A5027797567 @default.
• W2671458188 hasAuthorship W2671458188A5042896525 @default.
• W2671458188 hasAuthorship W2671458188A5065279082 @default.
• W2671458188 hasBestOaLocation W26714581881 @default.
• W2671458188 hasConcept C104317684 @default.
• W2671458188 hasConcept C120665830 @default.
• W2671458188 hasConcept C121332964 @default.
• W2671458188 hasConcept C142724271 @default.
• W2671458188 hasConcept C169822122 @default.
• W2671458188 hasConcept C187092789 @default.
• W2671458188 hasConcept C190283241 @default.
• W2671458188 hasConcept C203522944 @default.
• W2671458188 hasConcept C2779134260 @default.
• W2671458188 hasConcept C54355233 @default.
• W2671458188 hasConcept C70721500 @default.
• W2671458188 hasConcept C71924100 @default.
• W2671458188 hasConcept C86803240 @default.
• W2671458188 hasConcept C95444343 @default.
• W2671458188 hasConceptScore W2671458188C104317684 @default.
• W2671458188 hasConceptScore W2671458188C120665830 @default.
• W2671458188 hasConceptScore W2671458188C121332964 @default.
• W2671458188 hasConceptScore W2671458188C142724271 @default.
• W2671458188 hasConceptScore W2671458188C169822122 @default.
• W2671458188 hasConceptScore W2671458188C187092789 @default.
• W2671458188 hasConceptScore W2671458188C190283241 @default.
• W2671458188 hasConceptScore W2671458188C203522944 @default.
• W2671458188 hasConceptScore W2671458188C2779134260 @default.
• W2671458188 hasConceptScore W2671458188C54355233 @default.

• next