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• W26725033 abstract "Abstract This study looks into Monte-Carlo simulation methods that are used for radiotherapy and radiobiology studies. Although simulation methodologies for the two mentioned fields are quite different since one deals with macroscopic effects rather than the cellular scale effects in the case of the other, the results obtained by both fields are complementary for understanding radiation effects on cellular substructures and the resulting reactions of irradiated biological tissues. It has been concluded through the literature that the deoxyribonucleic acid (DNA) damage is the most important result to look at among other radio-induced lesions in the cell. Thus, most of the research projects on radiation damage including Monte-Carlo studies are now concentrated on radio-induced DNA breaks and cell repair activities. Among the simulation programs we can distinguish the general purpose codes that are mostly used for macroscopic calculations and the step by step track structure codes that are dedicated for sub-cellular scale simulations mostly dealing with particles interactions with the DNA structure. However, none of the proposed toolkits can completely cover all the simulation cases since we are usually limited by the lack of cross sections for a certain particle type and in a certain energy domain depending on the code content. This obstacle can be overridden by some approximations on the macroscopic scale but when it comes to submicron calculations the energy deposit patterns should be as precise as possible for radiobiological analysis. On the DNA scale, chemical reactions and free radicals diffusion through target media were taken into account in some studies considering also the DNA structure geometry in the simulation. Although this type of approaches is aiming to be as realistic as possible, it can be a complex task to reproduce and also very time consuming requiring an important computing power. So in an effort to simplify and accelerate the calculations, several alternative methods were developed by different authors giving an acceptable estimation of radio-induced DNA damage quantification and making this issue more accessible for quick studies. The work described in this chapter reviews some of the numerical calculations of basic microdosimetric quantities for particles that are generally used in hadrontherapy, mainly protons and carbon ions, taking into account the secondary electrons tracks that are generated in tissue-like media (water). Using the Geant4-DNA package of the Geant4 Monte-Carlo simulation toolkit it is possible to track particles in a step by step mode taking also advantage of the available geometry modules and the standard physics processes of the standard Geant4 toolkit. Simulations are then described and the DNA damage quantification algorithms are studied with an effort to show the link between ionizing track structure and the resulting damage yields. The results obtained by different numerical methods are compared together then a discussion describes the advantages of each of the mentioned calculations." @default.
• W26725033 created "2016-06-24" @default.
• W26725033 creator A5047709858 @default.
• W26725033 date "2013-01-01" @default.
• W26725033 modified "2023-10-05" @default.
• W26725033 title "Molecular Scale Simulation of Ionizing Particles Tracks for Radiobiology and Hadrontherapy Studies" @default.
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• W26725033 doi "https://doi.org/10.1016/b978-0-12-396455-7.00004-2" @default.
• W26725033 hasPublicationYear "2013" @default.
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