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- W267454927 abstract "Herpesvirus infections rarely cause significant problems in the immunocompetent human host. However, in the immunosuppressed, for example, recipients of hematopoietic stem cell transplants (HSCT) (Rooney et al., 1998), solid organ transplants (SOT), or human immunodeficiency virus (HIV)-infected individuals, viral infections/reactivations are common and are associated with considerable morbidity and mortality. The resultant uncontrolled infections correlate with a lack of cellular immunity against viral antigens (Weinberg et al., 2001). While effective antiviral drugs are available for the treatment of some herpesvirus infections, adoptive immunotherapy, which is the artificial reconstitution of virus-specific T-cells with in vitro expanded cytotoxic T-lymphocytes (CTLs), for the prophylaxis and/or treatment of herpesviruses is an attractive option. The γ-herpesvirus, Epstein–Barr virus (EBV) is also associated with a heterogeneous range of malignancies and diseases that occur in apparently immunocompetent individuals and since these malignancies also express “foreign” viral antigenic targets they may also be good candidates for immunotherapy (Rickinson and Kieff, 2001). The advances in such adopt ive immunotherapeutic approaches will be discussed in this chapter." @default.
- W267454927 created "2016-06-24" @default.
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- W267454927 creator A5020956671 @default.
- W267454927 creator A5057196933 @default.
- W267454927 creator A5086465061 @default.
- W267454927 date "2010-03-02" @default.
- W267454927 modified "2023-09-25" @default.
- W267454927 title "Adoptive immunotherapy for herpesviruses" @default.
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- W267454927 doi "https://doi.org/10.1017/cbo9780511545313.075" @default.
- W267454927 hasPublicationYear "2010" @default.